TY - JOUR
T1 - A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans
AU - Sullivan, Kathleen E.
AU - Wooten, Candra
AU - Schmeckpeper, Barbara J.
AU - Goldman, Daniel
AU - Petri, Michelle A.
PY - 1997/12
Y1 - 1997/12
N2 - Objective. The polymorphic tumor necrosis factor α (TNFα) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFα. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls. Methods. We determined the gene frequency of the polymorphic variant of TNFα in an African-American SLE patient population and in a geographically matched African-American control population. Results. The gene frequency of the TNFα - 308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles. Conclusion. The TNFα - 308A polymorphism is associated with an increased risk of SLE in African- Americans.
AB - Objective. The polymorphic tumor necrosis factor α (TNFα) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFα. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls. Methods. We determined the gene frequency of the polymorphic variant of TNFα in an African-American SLE patient population and in a geographically matched African-American control population. Results. The gene frequency of the TNFα - 308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles. Conclusion. The TNFα - 308A polymorphism is associated with an increased risk of SLE in African- Americans.
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U2 - 10.1002/art.1780401215
DO - 10.1002/art.1780401215
M3 - Article
C2 - 9416858
AN - SCOPUS:0031470562
SN - 0004-3591
VL - 40
SP - 2207
EP - 2211
JO - Arthritis and rheumatism
JF - Arthritis and rheumatism
IS - 12
ER -