A profile of patients with hyperparathyroidism undergoing lithium therapy for affective psychiatric disorders

Emad Kandil, Alan P. Dackiw, Haytham Alabbas, Obai Abdullah, Anthony P. Tufaro, Ralph P. Tufano

Research output: Contribution to journalArticle


Background Our objective was to evaluate whether lithium-induced hyperparathyroidism (LIHPT) is caused by single-gland versus multigland disease. Methods Medical records of 7 patients who underwent parathyroidectomy for LIHPT were reviewed. Results The mean preoperative calcium was 11.1 ± 0.7 mg/dL. Six of 7 patients were rendered eucalcemic with surgery. Of the 6 patients successfully treated with surgery, 4 had single-gland disease, 1 had double adenomas, and 1 had 4-gland hyperplasia. Intraoperative intact serum parathyroid hormone (iPTH) accurately predicted resolution of hyperparathyroidism in 6 of 7 patients. One patient then subsequently developed persistent hyperparathyroidism refractory to further surgery. Localization studies defined the extent of disease in 5 of 7 patients. Conclusion LIHPT presents with a spectrum of disease ranging from single-gland to multigland disease. The utility of preoperative localization studies and intraoperative iPTH in this population is uncertain. Bilateral exploration may be best to achieve a resolution of LIHPT. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalHead and Neck
Issue number7
StatePublished - Jul 1 2011



  • hyperparathyroidism
  • lithium therapy
  • parathyroid adenoma
  • parathyroid disease
  • parathyroid hyperplasia

ASJC Scopus subject areas

  • Otorhinolaryngology

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