A prion disease - Possible gerstmann-straussler-scheinker disease: A case report

Ayse Aralasmak, Barbara J. Crain, Wen Quan Zou, David Mark Yousem

Research output: Contribution to journalArticle

Abstract

A 50-year-old patient with a 6-month history of progressive cognitive and motor disability is presented. There were no myoclonic jerks on examination and no periodic sharp waves by electroencephalography. Imaging showed high signal on T2-weighted scans in the basal ganglia and posterior limbs of the internal capsules, with no restricted diffusion and parenchymal volume loss. A brain biopsy was performed. Western blot analysis revealed a protease-resistant prion protein fragment (PrP7-8), the molecular hallmark of Gerstmann-Straussler- Scheinker disease.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume30
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Gerstmann-Straussler-Scheinker Disease
Internal Capsule
Myoclonus
Prion Diseases
Basal Ganglia
Electroencephalography
Peptide Hydrolases
Extremities
Western Blotting
Biopsy
Brain
Prion Proteins

Keywords

  • Gerstmann-Straussler-Scheinker
  • Magnetic resonance imaging findings
  • Prion diseases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A prion disease - Possible gerstmann-straussler-scheinker disease : A case report. / Aralasmak, Ayse; Crain, Barbara J.; Zou, Wen Quan; Yousem, David Mark.

In: Journal of Computer Assisted Tomography, Vol. 30, No. 1, 01.2006, p. 135-139.

Research output: Contribution to journalArticle

Aralasmak, Ayse ; Crain, Barbara J. ; Zou, Wen Quan ; Yousem, David Mark. / A prion disease - Possible gerstmann-straussler-scheinker disease : A case report. In: Journal of Computer Assisted Tomography. 2006 ; Vol. 30, No. 1. pp. 135-139.
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