TY - JOUR
T1 - A priming dose of oral vitamin A given to preschool children may extend protection conferred by a subsequent large dose of vitamin A
AU - Humphrey, J. H.
AU - West, K. P.
AU - Muhilal,
AU - Lai Chu See, Chu See
AU - Natadisastra, G.
AU - Sommer, A.
PY - 1993
Y1 - 1993
N2 - A randomized trial tested whether a priming dose of vitamin A would extend the protection of a subsequent 60,000-μg retinol equivalent (RE) oral dose. Seventy-five xerophthalmic and 74 age- and neighborhood-matched non- xerophthalmic preschool children were randomized to one of three oral regimens of vitamin A, receiving peanut oil only (Group A), 7500 μg RE (Group B) or 60,000 μg RE (Group C), followed in all instances by 60,000 μg RE 1 wk later. Serum retinol was measured 2, 4, 6 and 12 mo following the second dose by technicians unaware of the children's treatment status. Among xerophthalmic children, mean values differed across treatment groups at 2 mo (C > A) and tended to be different at 12 mo (C > A and B > A). Among non- xerophthalmic children mean retinol concentrations differed across treatment groups at 6 mo, but not in a consistent way (A > C > B), and at 12 mo (C > A and B > A). Xerophthalmic children reverted to biochemical deficiency faster than non-xerophthalmic children. A small or large priming dose may extend the protection conferred by a 60,000-μg RE dose, supporting the use of repeated, spaced doses of vitamin A for treating xerophthalmia. Similar retinol concentrations in Groups B and C at 12 mo suggest the 60,000-μg RE prophylactic dose currently recommended by the World Health Organization need not be increased.
AB - A randomized trial tested whether a priming dose of vitamin A would extend the protection of a subsequent 60,000-μg retinol equivalent (RE) oral dose. Seventy-five xerophthalmic and 74 age- and neighborhood-matched non- xerophthalmic preschool children were randomized to one of three oral regimens of vitamin A, receiving peanut oil only (Group A), 7500 μg RE (Group B) or 60,000 μg RE (Group C), followed in all instances by 60,000 μg RE 1 wk later. Serum retinol was measured 2, 4, 6 and 12 mo following the second dose by technicians unaware of the children's treatment status. Among xerophthalmic children, mean values differed across treatment groups at 2 mo (C > A) and tended to be different at 12 mo (C > A and B > A). Among non- xerophthalmic children mean retinol concentrations differed across treatment groups at 6 mo, but not in a consistent way (A > C > B), and at 12 mo (C > A and B > A). Xerophthalmic children reverted to biochemical deficiency faster than non-xerophthalmic children. A small or large priming dose may extend the protection conferred by a 60,000-μg RE dose, supporting the use of repeated, spaced doses of vitamin A for treating xerophthalmia. Similar retinol concentrations in Groups B and C at 12 mo suggest the 60,000-μg RE prophylactic dose currently recommended by the World Health Organization need not be increased.
KW - Indonesia
KW - periodic vitamin A dosing
KW - preschool children
KW - vitamin A deficiency
KW - xerophthalmia
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M3 - Article
C2 - 8336206
AN - SCOPUS:0027265789
SN - 0022-3166
VL - 123
SP - 1363
EP - 1369
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 8
ER -