A preliminary study of medial temporal lobe function in youths with a history of caregiver deprivation and emotional neglect

Françoise S. Maheu, Mary Dozier, Amanda E. Guyer, Darcy Mandell, Elizabeth Peloso, Kaitlin Poeth, Jessica Jenness, Jennifer Y.F. Lau, John P. Ackerman, Daniel S. Pine, Monique Ernst

Research output: Contribution to journalArticlepeer-review

Abstract

Previous research findings have linked caregiver deprivation and emotional neglect with sensitivity to threatening cues. The present preliminary study investigated whether dysfunctions of the medial temporal lobe could underlie these associations. Using fMRI, we measured medial temporal lobe responses to emotional faces (angry, fearful, happy, neutral) among 30 youths. Eleven of the youths had a history of caregiver deprivation and emotional neglect. Attention states (i.e., attention to anger, fear, or physical attributes, or passive viewing) were systematically manipulated. Relative to comparison youths, youths with a history of caregiver deprivation and emotional neglect showed significantly greater left amygdala and left anterior hippocampus activation during the processing of threatening information. To our knowledge, these findings are the first to demonstrate altered medial temporal lobe function during the processing of threat cues in youths with a history of caregiver deprivation and emotional neglect.

Original languageEnglish (US)
Pages (from-to)34-49
Number of pages16
JournalCognitive, Affective and Behavioral Neuroscience
Volume10
Issue number1
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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