A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke

P. L.P. Morris, H. S. Mayberg, K. Bolla, D. F. Wong, R. F. Dannals, S. E. Starkstein, R. G. Robinson

Research output: Contribution to journalArticlepeer-review


Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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