A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke

P. L P Morris, H. S. Mayberg, K. Bolla, Dean Foster Wong, Robert F Dannals, S. E. Starkstein, R. G. Robinson

Research output: Contribution to journalArticle

Abstract

Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P <0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P <0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume5
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Serotonin 5-HT2 Receptors
Serotonin
Stroke
Neuropsychological Tests
Serotonin Receptors
Frontal Lobe
Positron-Emission Tomography
Cognition

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke. / Morris, P. L P; Mayberg, H. S.; Bolla, K.; Wong, Dean Foster; Dannals, Robert F; Starkstein, S. E.; Robinson, R. G.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 5, No. 4, 1993, p. 395-400.

Research output: Contribution to journalArticle

@article{4093044654fd45f998c0a0924f1b628b,
title = "A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke",
abstract = "Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P <0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P <0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.",
author = "Morris, {P. L P} and Mayberg, {H. S.} and K. Bolla and Wong, {Dean Foster} and Dannals, {Robert F} and Starkstein, {S. E.} and Robinson, {R. G.}",
year = "1993",
language = "English (US)",
volume = "5",
pages = "395--400",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "4",

}

TY - JOUR

T1 - A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke

AU - Morris, P. L P

AU - Mayberg, H. S.

AU - Bolla, K.

AU - Wong, Dean Foster

AU - Dannals, Robert F

AU - Starkstein, S. E.

AU - Robinson, R. G.

PY - 1993

Y1 - 1993

N2 - Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P <0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P <0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

AB - Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P <0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P <0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.

UR - http://www.scopus.com/inward/record.url?scp=0027379301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027379301&partnerID=8YFLogxK

M3 - Article

C2 - 8286937

AN - SCOPUS:0027379301

VL - 5

SP - 395

EP - 400

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 4

ER -