A Preliminary Study of Cardiopulmonary Resuscitation by Circumferential Compression of the Chest with Use of a Pneumatic Vest

Henry R. Halperin, Joshua E. Tsitlik, Mark Gelfand, Myron L. Weisfeldt, Kreg G. Gruben, Howard R. Levin, Barry K. Rayburn, Nisha C. Chandra, Carol Jack Scott, Billie J. Kreps, Cynthia O. Siu, Alan D. Guerci

Research output: Contribution to journalArticlepeer-review

Abstract

More than 300,000 people die each year of cardiac arrest. Studies have shown that raising vascular pressures during cardiopulmonary resuscitation (CPR) can improve survival and that vascular pressures can be raised by increasing intrathoracic pressure. To produce periodic increases in intrathoracic pressure, we developed a pneumatically cycled circumferential thoracic vest system and compared the results of the use of this system in CPR (vest CPR) with those of manual CPR. In phase 1 of the study, aortic and right-atrial pressures were measured during both vest CPR (60 inflations per minute) and manual CPR in 15 patients in whom a mean (±SD) of 42 ±16 minutes of initial manual CPR had been unsuccessful. Vest CPR was also carried out on 14 other patients in whom pressure measurements were not made. In phase 2 of the study, short-term survival was assessed in 34 additional patients randomly assigned to undergo vest CPR (17 patients) or continued manual CPR (17 patients) after initial manual CPR (duration, 11 ±4 minutes) had been unsuccessful. In phase 1 of the study, vest CPR increased the peak aortic pressure from 78 ±26 mm Hg to 138 ±28 mm Hg (P<0.001) and the coronary perfusion pressure from 15 ±8 mm Hg to 23 ±11 mm Hg (P<0.003). Despite prolonged unsuccessful manual CPR, spontaneous circulation returned with vest CPR in 4 of the 29 patients. In phase 2 of the study, spontaneous circulation returned in 8 of the 17 patients who underwent vest CPR as compared with only 3 of the 17 patients who received continued manual CPR (P = 0.14). More patients in the vest-CPR group than in the manual-CPR group were alive 6 hours after attempted resuscitation (6 of 17 vs. 1 of 17) and 24 hours after attempted resuscitation (3 of 17 vs. 1 of 17), but none survived to leave the hospital. In this preliminary study, vest CPR, despite its late application, successfully increased aortic pressure and coronary perfusion pressure, and there was an insignificant trend toward a greater likelihood of the return of spontaneous circulation with vest CPR than with continued manual CPR. The effect of vest CPR on survival, however, is currently unknown and will require further study., There are more than 300,000 victims of cardiac arrest each year, and attempts to resuscitate them are usually unsuccessful. Both laboratory studies13 and clinical studies4 have shown that the restoration of cardiac function after cardiac arrest is related to the vascular pressures generated during resuscitation, especially the coronary perfusion pressure. In addition, over the past decade, a number of studies3,58 have provided evidence that the cyclic increase in intrathoracic pressure produced by chest compression is an important mechanism for the generation of vascular pressure and flow during cardiopulmonary resuscitation (CPR). On the basis of the assumption that…

Original languageEnglish (US)
Pages (from-to)762-768
Number of pages7
JournalNew England Journal of Medicine
Volume329
Issue number11
DOIs
StatePublished - Sep 9 1993

ASJC Scopus subject areas

  • Medicine(all)

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