A predictive model of cell traction forces based on cell geometry

Christopher A. Lemmon, Lewis Romer

Research output: Contribution to journalArticle

Abstract

Recent work has indicated that the shape and size of a cell can influence how a cell spreads, develops focal adhesions, and exerts forces on the substrate. However, it is unclear how cell shape regulates these events. Here we present a computational model that uses cell shape to predict the magnitude and direction of forces generated by cells. The predicted results are compared to experimentally measured traction forces, and show that the model can predict traction force direction, relative magnitude, and force distribution within the cell using only cell shape as an input. Analysis of the model shows that the magnitude and direction of the traction force at a given point is proportional to the first moment of area about that point in the cell, suggesting that contractile forces within the cell act on the entire cytoskeletal network as a single cohesive unit. Through this model, we demonstrate that intrinsic properties of cell shape can facilitate changes in traction force patterns, independently of heterogeneous mechanical properties or signaling events within the cell.

Original languageEnglish (US)
JournalBiophysical Journal
Volume99
Issue number9
DOIs
StatePublished - Nov 3 2010

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Traction
Cell Shape
Focal Adhesions
Cell Size
Direction compound

ASJC Scopus subject areas

  • Biophysics

Cite this

A predictive model of cell traction forces based on cell geometry. / Lemmon, Christopher A.; Romer, Lewis.

In: Biophysical Journal, Vol. 99, No. 9, 03.11.2010.

Research output: Contribution to journalArticle

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