A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: Bridging the translational gap

Shikha Snigdha; Norton W. Milgram; Sherry L. Willis; Marylin Albert; S. Weintraub; Norbert J. Fortin; Carl W. Cotman

doi:10.1016/j.neurobiolaging.2013.01.018

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: Bridging the translational gap

Shikha Snigdha, Norton W. Milgram, Sherry L. Willis, Marylin Albert, S. Weintraub, Norbert J. Fortin, Carl W. Cotman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheimer's disease. The National Institute of Health (NIH) has led an initiative to develop a comprehensive Toolbox for Neurologic Behavioral Function (NIH Toolbox) to evaluate cognitive, motor, sensory and emotional function for use in epidemiologic and clinical studies spanning 3 to 85 years of age. This paper aims to analyze the strengths and limitations of animal behavioral tests that can be used to parallel those in the NIH Toolbox. We conclude that there are several paradigms available to define a preclinical battery that parallels the NIH Toolbox. We also suggest areas in which new tests may benefit the development of a comprehensive preclinical test battery for assessment of cognitive function in animal models of aging and Alzheimer's disease.

Original language	English (US)
Pages (from-to)	1891-1901
Number of pages	11
Journal	Neurobiology of aging
Volume	34
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.01.018
State	Published - Jul 2013

Keywords

Animal models
Attention
Episodic memory
Executive function
NIH Toolbox
Processing speed
Working memory

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2013.01.018

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abstract = "A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheimer's disease. The National Institute of Health (NIH) has led an initiative to develop a comprehensive Toolbox for Neurologic Behavioral Function (NIH Toolbox) to evaluate cognitive, motor, sensory and emotional function for use in epidemiologic and clinical studies spanning 3 to 85 years of age. This paper aims to analyze the strengths and limitations of animal behavioral tests that can be used to parallel those in the NIH Toolbox. We conclude that there are several paradigms available to define a preclinical battery that parallels the NIH Toolbox. We also suggest areas in which new tests may benefit the development of a comprehensive preclinical test battery for assessment of cognitive function in animal models of aging and Alzheimer's disease.",

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AU - Albert, Marylin

AU - Weintraub, S.

AU - Fortin, Norbert J.

AU - Cotman, Carl W.

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A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: Bridging the translational gap

Abstract

Keywords

ASJC Scopus subject areas

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