A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

Alexandre Iannello, Suzanne Samarani, Ossama Allam, Mohammad Ali Jenabian, Vikram Mehraj, Devendra Amre, Jean Pierre Routy, Cécile Tremblay, Ali Ahmad

Research output: Contribution to journalArticlepeer-review

Abstract

An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalCytokine
Volume90
DOIs
StatePublished - Feb 1 2017

Keywords

  • AIDS
  • HIV-1
  • IL-18
  • IL-18BP
  • Long-Term Non-Progressors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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