A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

Lawrence T. Wang, Lais S. Pereira, Yevel Flores-Garcia, James O'Connor, Barbara J. Flynn, Arne Schön, Nicholas K. Hurlburt, Marlon Dillon, Annie S.P. Yang, Amanda Fabra-García, Azza H. Idris, Bryan T. Mayer, Monica W. Gerber, Raphael Gottardo, Rosemarie D. Mason, Nicole Cavett, Reid B. Ballard, Neville K. Kisalu, Alvaro Molina-Cruz, Jorgen NelsonRachel Vistein, Carolina Barillas-Mury, Rogerio Amino, David Baker, Neil P. King, Robert W. Sauerwein, Marie Pancera, Ian A. Cockburn, Fidel Zavala, Joseph R. Francica, Robert A. Seder

Research output: Contribution to journalArticlepeer-review

Abstract

Wang et al. isolate a potent neutralizing human mAb, L9 that preferentially binds NVDP minor repeats of Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites with high affinity while cross-reacting with NANP major repeats. Their findings define the subdominant PfCSP minor repeats as neutralizing epitopes and demonstrate that the liver is an important site for antibodies to prevent malaria.

Original languageEnglish (US)
Pages (from-to)733-744.e8
JournalImmunity
Volume53
Issue number4
DOIs
StatePublished - Oct 13 2020

Keywords

  • Monoclonal antibodies
  • NVDP minor repeats
  • Plasmodium falciparum
  • circumsporozoite protein
  • malaria vaccines
  • passive transfer
  • sporozoites

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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