@article{417275cd6c594950a12cdba8547998a9,
title = "A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver",
abstract = "Wang et al. isolate a potent neutralizing human mAb, L9 that preferentially binds NVDP minor repeats of Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites with high affinity while cross-reacting with NANP major repeats. Their findings define the subdominant PfCSP minor repeats as neutralizing epitopes and demonstrate that the liver is an important site for antibodies to prevent malaria.",
keywords = "Monoclonal antibodies, NVDP minor repeats, Plasmodium falciparum, circumsporozoite protein, malaria vaccines, passive transfer, sporozoites",
author = "Wang, {Lawrence T.} and Pereira, {Lais S.} and Yevel Flores-Garcia and James O'Connor and Flynn, {Barbara J.} and Arne Sch{\"o}n and Hurlburt, {Nicholas K.} and Marlon Dillon and Yang, {Annie S.P.} and Amanda Fabra-Garc{\'i}a and Idris, {Azza H.} and Mayer, {Bryan T.} and Gerber, {Monica W.} and Raphael Gottardo and Mason, {Rosemarie D.} and Nicole Cavett and Ballard, {Reid B.} and Kisalu, {Neville K.} and Alvaro Molina-Cruz and Jorgen Nelson and Rachel Vistein and Carolina Barillas-Mury and Rogerio Amino and David Baker and King, {Neil P.} and Sauerwein, {Robert W.} and Marie Pancera and Cockburn, {Ian A.} and Fidel Zavala and Francica, {Joseph R.} and Seder, {Robert A.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = oct,
day = "13",
doi = "10.1016/j.immuni.2020.08.014",
language = "English (US)",
volume = "53",
pages = "733--744.e8",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}