A postmortem study of the effect of chronic opiate abuse on psychotomimetic binding sites of human frontal cortex

Richard B. Rothman, Victor Bykov, Jean L. Cadet, Joel E. Kleinman

Research output: Contribution to journalArticlepeer-review

Abstract

Membranes were prepared from area 8 of human frontal cortex harvested from five controls and five opiate addicts. Psychotomimetic binding sites were assayed using tritiated 1-(1-[2-thiethyl]cyclohexyl)piperidine ([3H]TCP) to label phencyclidine binding sites and 1,3-Di(2-[5-3H]tolyl)guanidine ([3H]DTG) to label the "haldoperidol-sensitive sigma binding site." The results demonstrated no significant differences between the control and experimental groups, suggesting that in the region of the human brain sampled in this study, chronic abuse of opiates is not accompianed by alterations in psychotomimetic binding sites.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalNeuropeptides
Volume10
Issue number3
DOIs
StatePublished - Oct 1987
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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