A possible subcellular mechanism underlying the "French paradox": The opening of mitochondrial K ATP channels

Ernesto A. Aiello, Horacio E. Cingolani

Research output: Contribution to journalArticlepeer-review

Abstract

A reduction in the risk of coronary heart disease has been associated to moderate red wine consumption. We tested whether a nonalcoholic red wine extract would open mitochondrial K ATP channels in guinea pig myocytes. The opening of mitochondrial KATP channels was assessed by endogenous flavoprotein fluorescence. Red wine extract (100 mg·mL -1) increased flavoprotein oxidation (10.9% ± 1.2%, n = 20). This effect was prevented by the mitochondrial K ATP channel blocker, 5-hydroxydecanoate (500 μmol·L -1; 0.3% ± 1.1%, n = 13), confirming the hypothesis that red wine extract opens mitochondrial K ATP channels.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
JournalApplied Physiology, Nutrition and Metabolism
Volume36
Issue number5
DOIs
StatePublished - Oct 1 2011

Keywords

  • Cardioprotection
  • MitoKATP channels
  • Red wine extract

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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