A possible role for cold insoluble globulin in chemotactic factor mediated polymorphonuclear leukocyte adherence to plastic

Philip J. Spagnuolo, Michael M. Lederman, John Schiltz, Jerrold Ellner, Lloyd Culp

Research output: Contribution to journalArticle

Abstract

We examined the potential role of fibronectin in chemotactic factor stimulation of neutrophil adherence to plastic. Monoclonal antibody to human fibronectin significantly reduced chemotactic peptide stimulation of adherence but did not reduce adherence stimulated by phorbol myristate acetate or aggregation stimulated by either agent. Stimulation of neutrophils by chemotactic peptide was also associated with loss of cell surface fibronectin detected by immunofluorescence or binding of radiolabeled collagen. These data suggest that chemotactic peptides stimulate neutrophils to release Fn and that Fn mediates the attachment of neutrophils to plastic surfaces.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume106
Issue number2
DOIs
StatePublished - May 31 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Fingerprint Dive into the research topics of 'A possible role for cold insoluble globulin in chemotactic factor mediated polymorphonuclear leukocyte adherence to plastic'. Together they form a unique fingerprint.

  • Cite this