"A Positron-emitting internal marker for identification of normal tissue by positron emission tomography

Phantom studies and validation in Patients," (Molecular Imaging and Biology (2003) vol. 5 (2) 79-85))

Cherry T. Thomas, Charles R. Meyer, Robert A. Koeppe, Gregory P. Kalemkerian, Susan J. Fisher, Terry L. Dull, Kenneth R. Zasadny, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

Purpose: This study evaluated in a phantom model and verified in patients with lung cancer whether the use of an internal positron-emitting labeled marker could localize a critical structure by position emission tomography (PET) imaging and verify multimodality image registration. Materials and methods: An initial device and method were developed to demonstrate by dedicated PET the location of the normal esophagus in a phantom and in three patients using a column of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) solution between proximal and distal gas phases in polyurethane tubing. The device was assessed for possible loss of radioactivity. PET, CT and PET-CT fusion imaging followed. Results: X-rays of the marker device showed a continuous fluid column. No leakage of contents was detected. The internal marker in the phantom and in patients allowed visualization by PET of the esophagus, and verified an image registration algorithm. Conclusions: A position-emitting internal marker was constructed, demonstrated to retain tracer, and shown to be capable of verifying an image registration algorithm and identifying a critical structure, the esophagus, by PET in a phantom and in patients.

Original languageEnglish (US)
Pages (from-to)278-279
Number of pages2
JournalMolecular Imaging and Biology
Volume5
Issue number4
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Molecular Imaging
Validation Studies
Positron-Emission Tomography
Molecular Biology
Tomography
Electrons
Esophagus
Equipment and Supplies
Polyurethanes
Fluorodeoxyglucose F18
Radioactivity
Lung Neoplasms
Gases
X-Rays

Keywords

  • Fluorine-18
  • Image registration
  • Internal marker
  • Neoplasms
  • PET
  • Radiation treatment planning

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Radiology Nuclear Medicine and imaging

Cite this

"A Positron-emitting internal marker for identification of normal tissue by positron emission tomography : Phantom studies and validation in Patients," (Molecular Imaging and Biology (2003) vol. 5 (2) 79-85)). / Thomas, Cherry T.; Meyer, Charles R.; Koeppe, Robert A.; Kalemkerian, Gregory P.; Fisher, Susan J.; Dull, Terry L.; Zasadny, Kenneth R.; Wahl, Richard L.

In: Molecular Imaging and Biology, Vol. 5, No. 4, 07.2003, p. 278-279.

Research output: Contribution to journalArticle

Thomas, Cherry T. ; Meyer, Charles R. ; Koeppe, Robert A. ; Kalemkerian, Gregory P. ; Fisher, Susan J. ; Dull, Terry L. ; Zasadny, Kenneth R. ; Wahl, Richard L. / "A Positron-emitting internal marker for identification of normal tissue by positron emission tomography : Phantom studies and validation in Patients," (Molecular Imaging and Biology (2003) vol. 5 (2) 79-85)). In: Molecular Imaging and Biology. 2003 ; Vol. 5, No. 4. pp. 278-279.
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