A positive association between leptin and blood pressure of normal range in Japanese men

Keiko Wada, Hiroshi Yatsuka, Koji Tamakoshi, Rei Otsuka, Chie Fujii, Kunihiro Matsushita, Kaichiro Sugiura, Hideaki Toyoshima

Research output: Contribution to journalArticle

Abstract

The results of previous studies on the relationship between leptin and blood pressure are discordant. We investigated to what extent the serum leptin level was related to blood pressure independent of the degree of insulin resistance. The subjects were 1,916 men aged 34-69 years whose mean body mass index (BMI) was 23.0 kg/M2. Blood pressure was regressed by leptin concentrations with adjustments for age, BMI, insulin resistance, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, physical activity, drinking habits and smoking status. Leptin was associated with diastolic blood pressure (DBP) (standardized β: 0.092, p=0.003), but not with systolic blood pressure (SBP) (standardized β: 0.035, p=0.25), although insulin resistance was positively associated with both SBP and DBP (standardized β 0.175 for SBP, p

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalHypertension Research
Volume29
Issue number7
DOIs
StatePublished - Jul 2006
Externally publishedYes

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Leptin
Reference Values
Blood Pressure
Insulin Resistance
Body Mass Index
LDL Cholesterol
HDL Cholesterol
Drinking
Habits
Triglycerides
Smoking
Exercise

Keywords

  • Blood pressure
  • Body mass index
  • Epidemiology
  • Insulin resistance
  • Leptin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

A positive association between leptin and blood pressure of normal range in Japanese men. / Wada, Keiko; Yatsuka, Hiroshi; Tamakoshi, Koji; Otsuka, Rei; Fujii, Chie; Matsushita, Kunihiro; Sugiura, Kaichiro; Toyoshima, Hideaki.

In: Hypertension Research, Vol. 29, No. 7, 07.2006, p. 485-492.

Research output: Contribution to journalArticle

Wada, K, Yatsuka, H, Tamakoshi, K, Otsuka, R, Fujii, C, Matsushita, K, Sugiura, K & Toyoshima, H 2006, 'A positive association between leptin and blood pressure of normal range in Japanese men', Hypertension Research, vol. 29, no. 7, pp. 485-492. https://doi.org/10.1291/hypres.29.485
Wada, Keiko ; Yatsuka, Hiroshi ; Tamakoshi, Koji ; Otsuka, Rei ; Fujii, Chie ; Matsushita, Kunihiro ; Sugiura, Kaichiro ; Toyoshima, Hideaki. / A positive association between leptin and blood pressure of normal range in Japanese men. In: Hypertension Research. 2006 ; Vol. 29, No. 7. pp. 485-492.
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