A population study of Alzheimer's disease: Findings from the Cache County Study on Memory, Health, and Aging

Jo Ann T. Tschanz, Katherine Treiber, Maria C. Norton, Kathleen A. Welsh-Bohmer, Leslie Toone, Peter P. Zandi, Christine A. Szekely, Constantine Lyketsos, John C.S. Breitner, James Anthony, Erin Bigler, James Burke, Robert C. Green, Liz Klein, Carol Leslie, Ronald Munger, Truls Østbye, Carl Pieper, Brenda Plassman, David C. SteffensJeannette J. Townsend, Bonita W. Wyse, Michael Williams

Research output: Contribution to journalArticle


There are several population-base studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been following an initial cohort of 5,092 seniors since 1995, has reported among its major findings the role of the Apolipoprotein E gene on modifying the risk for Alzheimer's disease (AD) in males and females and identifying pharmacologic compounds that may act to reduce AD risk. This article summarizes the major findings of the Cache County study to date, describes ongoing investigations, and reports preliminary analyses on the outcome of the oldest-old in this population, the subgroup of participants who were over age 84 at the study's inception.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalCare Management Journals
Issue number2
StatePublished - Jun 1 2005



  • Alzheimer's disease
  • Alzheimer's prevention
  • Dementia
  • Epidemiology

ASJC Scopus subject areas

  • Health Policy

Cite this

Tschanz, J. A. T., Treiber, K., Norton, M. C., Welsh-Bohmer, K. A., Toone, L., Zandi, P. P., Szekely, C. A., Lyketsos, C., Breitner, J. C. S., Anthony, J., Bigler, E., Burke, J., Green, R. C., Klein, L., Leslie, C., Munger, R., Østbye, T., Pieper, C., Plassman, B., ... Williams, M. (2005). A population study of Alzheimer's disease: Findings from the Cache County Study on Memory, Health, and Aging. Care Management Journals, 6(2), 107-114. https://doi.org/10.1891/cmaj.6.2.107