A population-based, prospective study of blood pressure and risk for end-stage renal disease in China

Kristi Reynolds, Dongfeng Gu, Paul Muntner, John W. Kusek, Jing Chen, Xigui Wu, Xiufang Duan, Chung Shiuan Chen, Michael John Klag, Paul K. Whelton, Jiang He

Research output: Contribution to journalArticle

Abstract

The association between BP and risk for ESRD has not been well characterized in Asian populations. This study examined the relationship between level of BP and incidence of ESRD in a prospective cohort study of 158,365 Chinese men and women who were 40 yr and older. Measurement of BP and covariables were made in 1991 following a standard protocol. Follow-up evaluations were conducted in 1999 to 2000 and included interviewing participants or proxies and obtaining medical records and death certificates for ESRD cases. During 1,236,422 person-years of follow-up, 380 participants initiated renal replacement therapy or died from renal failure (30.7 cases per 100,000 person-years). Compared with those with normal BP, the multivariate adjusted hazard ratios (95% confidence interval) of all-cause ESRD for prehypertension and stage 1 and stage 2 hypertension were 1.30 (0.98 to 1.74), 1.47 (1.06 to 2.06), and 2.60 (1.89 to 3.57), respectively (P <0.001 for trend). The corresponding hazard ratios (95% confidence interval) of glomerulonephritis-related ESRD were 1.32 (0.82 to 2.11), 1.48 (0.83 to 2.61), and 3.40 (2.02 to 5.74), respectively (P

Original languageEnglish (US)
Pages (from-to)1928-1935
Number of pages8
JournalJournal of the American Society of Nephrology
Volume18
Issue number6
DOIs
StatePublished - Jun 2007

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Chronic Kidney Failure
China
Prospective Studies
Blood Pressure
Population
Prehypertension
Confidence Intervals
Death Certificates
Renal Replacement Therapy
Proxy
Glomerulonephritis
Medical Records
Renal Insufficiency
Cohort Studies
Hypertension
Incidence

ASJC Scopus subject areas

  • Nephrology

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A population-based, prospective study of blood pressure and risk for end-stage renal disease in China. / Reynolds, Kristi; Gu, Dongfeng; Muntner, Paul; Kusek, John W.; Chen, Jing; Wu, Xigui; Duan, Xiufang; Chen, Chung Shiuan; Klag, Michael John; Whelton, Paul K.; He, Jiang.

In: Journal of the American Society of Nephrology, Vol. 18, No. 6, 06.2007, p. 1928-1935.

Research output: Contribution to journalArticle

Reynolds, K, Gu, D, Muntner, P, Kusek, JW, Chen, J, Wu, X, Duan, X, Chen, CS, Klag, MJ, Whelton, PK & He, J 2007, 'A population-based, prospective study of blood pressure and risk for end-stage renal disease in China', Journal of the American Society of Nephrology, vol. 18, no. 6, pp. 1928-1935. https://doi.org/10.1681/ASN.2006111199
Reynolds, Kristi ; Gu, Dongfeng ; Muntner, Paul ; Kusek, John W. ; Chen, Jing ; Wu, Xigui ; Duan, Xiufang ; Chen, Chung Shiuan ; Klag, Michael John ; Whelton, Paul K. ; He, Jiang. / A population-based, prospective study of blood pressure and risk for end-stage renal disease in China. In: Journal of the American Society of Nephrology. 2007 ; Vol. 18, No. 6. pp. 1928-1935.
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