TY - JOUR
T1 - A population-based evaluation of glaucoma screening
T2 - The baltimore eye survey
AU - Tielsch, James M.
AU - Katz, Joanne
AU - Singh, Kuldev
AU - Quigley, Harry A.
AU - Gottsch, John D.
AU - Javitt, Jonathan
AU - Sommer, Alfred
N1 - Funding Information:
Supported by grants EY-05091 and RR-04060 from the National Institutes of Health.
PY - 1991/11/15
Y1 - 1991/11/15
N2 - The Baltimore Eye Survey was a population-based survey conducted from January 1985 to November 1988 among residents of east Baltimore, Maryland, who were 40 years of age or older. A total of 5,308 black subjects and white subjects received a comprehensive screening examination for glaucoma including tonometry, visual fields, stereoscopic fundus photography, and a detailed medical and ophthalmic history. Based on a definitive examination, a diagnosis of glaucoma of any type was made for 196 persons. Tonometry, cup:disc ratio, and narrowest neuroretinal rim width were evaluated for their ability to correctly classify subjects into diseased or nondiseased states. There were no cutoff values at which these variables provided a reasonable balance of sensitivity and specificity, separately or in combination. Logistic regression models were fit that included demographic and other risk factors. Sensitivities and specificities were calculated for varying cutoff levels on the distribution of predicted probabilities. There was no cutoff for which reasonable sensitivity and specificity were obtained. The authors conclude that the effectiveness of current techniques for glaucoma screening is limited. Am J Epidemiol 1991 ;134:1102-10
AB - The Baltimore Eye Survey was a population-based survey conducted from January 1985 to November 1988 among residents of east Baltimore, Maryland, who were 40 years of age or older. A total of 5,308 black subjects and white subjects received a comprehensive screening examination for glaucoma including tonometry, visual fields, stereoscopic fundus photography, and a detailed medical and ophthalmic history. Based on a definitive examination, a diagnosis of glaucoma of any type was made for 196 persons. Tonometry, cup:disc ratio, and narrowest neuroretinal rim width were evaluated for their ability to correctly classify subjects into diseased or nondiseased states. There were no cutoff values at which these variables provided a reasonable balance of sensitivity and specificity, separately or in combination. Logistic regression models were fit that included demographic and other risk factors. Sensitivities and specificities were calculated for varying cutoff levels on the distribution of predicted probabilities. There was no cutoff for which reasonable sensitivity and specificity were obtained. The authors conclude that the effectiveness of current techniques for glaucoma screening is limited. Am J Epidemiol 1991 ;134:1102-10
KW - Glaucoma
KW - Sensitivity and specificity (epidemiology)
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U2 - 10.1093/oxfordjournals.aje.a116013
DO - 10.1093/oxfordjournals.aje.a116013
M3 - Article
C2 - 1746520
AN - SCOPUS:0026331292
SN - 0002-9262
VL - 134
SP - 1102
EP - 1110
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 10
ER -