A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors

Kah Jing Lim, Savita Bisht, Eli E. Bar, Anirban Maitra, Charles G. Eberhart

Research output: Contribution to journalArticlepeer-review

Abstract

Curcumin is a polyphenolic compound derived from the Indian spice turmeric. We used nanoparticle-encapsulated curcumin to treat medulloblastoma and glioblastoma cells. This formulation caused a dose-dependent decrease in growth of multiple brain tumor cell cultures, including the embryonal tumor derived lines DAOY and D283Med, and the glioblastoma neurosphere lines HSR-GBM1 and JHH -GBM14. The reductions in viable cell mass observed were associated with a combination of G 2/M arrest and apoptotic induction. Curcumin also significantly decreased anchorage-independent clonogenic growth and reduced the CD133-positive stem-like population. Downregulation of the insulin-like growth factor pathway in DAOY medulloblastoma cells was observed, providing one possible mechanism for the changes. Levels of STAT3 were also attenuated. Hedgehog signaling was blocked in DAOY cells but Notch signaling was not inhibited. Our data suggest that curcumin nanoparticles can inhibit malignant brain tumor growth through the modulation of cell proliferation, survival and stem cell phenotype.

Original languageEnglish (US)
Pages (from-to)464-473
Number of pages10
JournalCancer Biology and Therapy
Volume11
Issue number5
DOIs
StatePublished - Mar 1 2011

Keywords

  • Curcumin
  • Glioblastoma
  • Hedgehog
  • IGF
  • Medulloblastoma
  • NanoCurc™
  • Nanocurcumin

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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