A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

A. P. Kozikowski; D. Simoni; P. G. Baraldi; I. Lampronti; S. Manfredini

doi:10.1016/0960-894X(96)00037-6

A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

A. P. Kozikowski, D. Simoni, P. G. Baraldi, I. Lampronti, S. Manfredini

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

Original language	English (US)
Pages (from-to)	441-444
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0960-894X(96)00037-6
State	Published - Feb 20 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/0960-894X(96)00037-6

Cite this

@article{9596d022bafe42f7aab7470a5821684d,

title = "A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues",

abstract = "The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.",

author = "Kozikowski, {A. P.} and D. Simoni and Baraldi, {P. G.} and I. Lampronti and S. Manfredini",

year = "1996",

month = feb,

day = "20",

doi = "10.1016/0960-894X(96)00037-6",

language = "English (US)",

volume = "6",

pages = "441--444",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

AU - Kozikowski, A. P.

AU - Simoni, D.

AU - Baraldi, P. G.

AU - Lampronti, I.

AU - Manfredini, S.

PY - 1996/2/20

Y1 - 1996/2/20

N2 - The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

AB - The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

UR - http://www.scopus.com/inward/record.url?scp=0029924512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029924512&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(96)00037-6

DO - 10.1016/0960-894X(96)00037-6

M3 - Article

AN - SCOPUS:0029924512

SN - 0960-894X

VL - 6

SP - 441

EP - 444

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this