A PLE-based resolution of cocaine, pseudococaine, and 6-and 7-methoxylated cocaine analogues

A. P. Kozikowski, D. Simoni, P. G. Baraldi, I. Lampronti, S. Manfredini

Research output: Contribution to journalArticlepeer-review

Abstract

The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number4
DOIs
StatePublished - Feb 20 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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