A platelet-inspired paradigm for nanomedicine targeted to multiple diseases

Christa L. Modery-Pawlowski, Hsiao Hsuan Kuo, William M. Baldwin, Anirban Sen Gupta

Research output: Contribution to journalArticle

Abstract

Platelets are megakaryocyte-derived anucleated cells found in the blood. They are mainly responsible for rendering hemostasis or clotting to prevent bleeding complications. Decreased platelet numbers or deficiencies in platelet functions can lead to various acute or chronic bleeding conditions and hemorrhage. On the other hand, dysregulated hyperactivity of the clotting process can lead to thrombosis and vascular occlusion. There is significant evidence that beyond hemostasis and thrombosis, platelets play crucial mechanistic roles in other disease scenarios such as inflammation, immune response and cancer metastasis by mediating several cell-cell and cell-matrix interactions, as well as aiding the disease microenvironment via secretion of multiple soluble factors. Therefore, elucidating these mechanistic functions of platelets can provide unique avenues for developing platelet-inspired nanomedicine strategies targeted to these diseases. To this end, the current review provides detailed mechanistic insight into platelets' disease-relevant functions and discusses how these mechanisms can be utilized to engineer targeted nanomedicine systems.

Original languageEnglish (US)
Pages (from-to)1709-1727
Number of pages19
JournalNanomedicine
Volume8
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Nanomedicine
Medical nanotechnology
Platelets
Blood Platelets
paradigm
Disease
Hemorrhage
Hemostasis
Thrombosis
immune response
secretion
engineer
cancer
Megakaryocytes
blood
scenario
Platelet Count
Cell Communication
matrix
Blood Vessels

Keywords

  • drug delivery
  • hemostasis
  • immune response
  • inflammation
  • metastasis
  • platelet
  • platelet-inspired nanomedicine
  • thrombosis

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Cite this

Modery-Pawlowski, C. L., Kuo, H. H., Baldwin, W. M., & Gupta, A. S. (2013). A platelet-inspired paradigm for nanomedicine targeted to multiple diseases. Nanomedicine, 8(10), 1709-1727. https://doi.org/10.2217/nnm.13.113

A platelet-inspired paradigm for nanomedicine targeted to multiple diseases. / Modery-Pawlowski, Christa L.; Kuo, Hsiao Hsuan; Baldwin, William M.; Gupta, Anirban Sen.

In: Nanomedicine, Vol. 8, No. 10, 10.2013, p. 1709-1727.

Research output: Contribution to journalArticle

Modery-Pawlowski, CL, Kuo, HH, Baldwin, WM & Gupta, AS 2013, 'A platelet-inspired paradigm for nanomedicine targeted to multiple diseases', Nanomedicine, vol. 8, no. 10, pp. 1709-1727. https://doi.org/10.2217/nnm.13.113
Modery-Pawlowski CL, Kuo HH, Baldwin WM, Gupta AS. A platelet-inspired paradigm for nanomedicine targeted to multiple diseases. Nanomedicine. 2013 Oct;8(10):1709-1727. https://doi.org/10.2217/nnm.13.113
Modery-Pawlowski, Christa L. ; Kuo, Hsiao Hsuan ; Baldwin, William M. ; Gupta, Anirban Sen. / A platelet-inspired paradigm for nanomedicine targeted to multiple diseases. In: Nanomedicine. 2013 ; Vol. 8, No. 10. pp. 1709-1727.
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