A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes

J. M. Douglas, F. N. Judson, M. J. Levin, J. A. Bosso, S. L. Spruance, J. M. Johnston, L. Corey, J. A. McMillan, L. B. Weiner, J. A. Frank

Research output: Contribution to journalArticlepeer-review


Arildone is an aryl diketone which is inhibitory in vitro against herpes simplex virus type 2 at a concentration of 2 μg/ml or less. One hundred forty-five patients with recurrent genital herpes were enrolled in a multicenter, randomized, placebo-controlled, double-blind trial to evaluate the efficacy and safety of an 8% arildone cream. Patients initiated therapy a mean of 9.9 h and a maximum of 24 h after the reported onset of lesions and applied medication 6 times daily for 7 days. The duration of viral shedding was shorter among women (P < 0.05) and the duration of local itching was shorter among men (P < 0.05) in patients that received arildone than in those that received placebo, but there were no significant differences between treatment groups in duration of pain, time to crusting or healing of lesions, or percentage of patients developing new lesions. Mild local irritation after application of ointment was common and occurred equally in both treatment groups. Despite early application, topical arildone cream was ineffective in the therapy of acute recurrences of genital herpes.

Original languageEnglish (US)
Pages (from-to)464-467
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number3
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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