A pivotal role for p53: Balancing aerobic respiration and glycolysis

Wenzhe Ma, Ho Joong Sung, Joon Y. Park, Satoaki Matoba, Paul M. Hwang

Research output: Contribution to journalArticle

Abstract

The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalJournal of Bioenergetics and Biomembranes
Volume39
Issue number3
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Keywords

  • Cytochrome c oxidase
  • Synthesis of cytochrome c oxidase 2
  • Tumor protein p53

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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