Abstract
Benign rolandic epilepsy (BRE) and Landau-Kleffner syndrome (LKS) are similar epilepsy syndromes with sleep-accentuated epileptiform activity, sporadic seizures, and language dysfunction. Levetiracetam has been associated with improved language function in LKS and seizure reduction in BRE. We hypothesized levetiracetam would improve language function in children with BRE. A pilot study was performed with six children (aged 6-12) with BRE and evidence of impaired auditory comprehension and verbal memory. Children were transitioned from their current anticonvulsant to 40 mg/kg/day levetiracetam over a 2-week period and retested at 6 months. At 6 months, three of four children with baseline auditory comprehension impairments performed normally (P = 0.06), and five had improved auditory verbal memory (P = 0.08). Seizures improved in five, decreasing from 2.7 to 1.0 seizure per 6 months (P = 0.11). Results from this pilot study suggest that levetiracetam may have a beneficial effect on language in children with BRE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 514-517 |
| Number of pages | 4 |
| Journal | Epilepsy and Behavior |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2007 |
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Keywords
- Benign rolandic
- Centrotemporal
- Children
- Language
- Levetiracetam
- Seizures
ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Neurology
Cite this
A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy. / Kossoff, Eric H; Los, Jenna G.; Boatman, Dana F.
In: Epilepsy and Behavior, Vol. 11, No. 4, 12.2007, p. 514-517.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy
AU - Kossoff, Eric H
AU - Los, Jenna G.
AU - Boatman, Dana F
PY - 2007/12
Y1 - 2007/12
N2 - Benign rolandic epilepsy (BRE) and Landau-Kleffner syndrome (LKS) are similar epilepsy syndromes with sleep-accentuated epileptiform activity, sporadic seizures, and language dysfunction. Levetiracetam has been associated with improved language function in LKS and seizure reduction in BRE. We hypothesized levetiracetam would improve language function in children with BRE. A pilot study was performed with six children (aged 6-12) with BRE and evidence of impaired auditory comprehension and verbal memory. Children were transitioned from their current anticonvulsant to 40 mg/kg/day levetiracetam over a 2-week period and retested at 6 months. At 6 months, three of four children with baseline auditory comprehension impairments performed normally (P = 0.06), and five had improved auditory verbal memory (P = 0.08). Seizures improved in five, decreasing from 2.7 to 1.0 seizure per 6 months (P = 0.11). Results from this pilot study suggest that levetiracetam may have a beneficial effect on language in children with BRE.
AB - Benign rolandic epilepsy (BRE) and Landau-Kleffner syndrome (LKS) are similar epilepsy syndromes with sleep-accentuated epileptiform activity, sporadic seizures, and language dysfunction. Levetiracetam has been associated with improved language function in LKS and seizure reduction in BRE. We hypothesized levetiracetam would improve language function in children with BRE. A pilot study was performed with six children (aged 6-12) with BRE and evidence of impaired auditory comprehension and verbal memory. Children were transitioned from their current anticonvulsant to 40 mg/kg/day levetiracetam over a 2-week period and retested at 6 months. At 6 months, three of four children with baseline auditory comprehension impairments performed normally (P = 0.06), and five had improved auditory verbal memory (P = 0.08). Seizures improved in five, decreasing from 2.7 to 1.0 seizure per 6 months (P = 0.11). Results from this pilot study suggest that levetiracetam may have a beneficial effect on language in children with BRE.
KW - Benign rolandic
KW - Centrotemporal
KW - Children
KW - Language
KW - Levetiracetam
KW - Seizures
UR - http://www.scopus.com/inward/record.url?scp=36549081326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36549081326&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2007.07.011
DO - 10.1016/j.yebeh.2007.07.011
M3 - Article
C2 - 17936689
AN - SCOPUS:36549081326
VL - 11
SP - 514
EP - 517
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 4
ER -