A pilot study on the seroprevalence of parvovirus B19 infection

Mary Abraham, Rajeev Rudraraju, Rajesh Kannangai, Koshy George, Thomas Cherian, Dolly Daniel, Sandeep Ramalingam, Gopalan Sridharan

Research output: Contribution to journalArticle

Abstract

Background & objectives: Human parvovirus B 19 (PVB 19) causes aplastic crisis in children with congenital haemolytic anaemia, erythema infectiosum, abortion and stillbirth. Since data on PVB 19 prevalence is lacking in India, a pilot study was undertaken to estimate the prevalence of IgG antibody in children and adults. Methods: The samples were obtained from children attending our hospital and from volunteer blood donors, majority of whom were from south India. They included 45 children aged 1-5 yr, 39 aged 6-10 yr, 42 aged 11-15 yr and 100 healthy blood donors > 15 yr of age. Sera were tested for the presence of antibody to PVB 19 using a commercial enzyme immuno assay (EIA). Results: Of 226 samples tested, 113 (50%) were positive for PVB 19 IgG. The prevalence of antibody increased from 8.9 per cent at 1-5 yr to 70 per cent in those >15 yr : the median age of infection was between 6 and 15 yr. Sex and domiciliary status did not have significant effect on the prevalence of antibody. The IgG antibody index increased significantly with age, suggesting repeated exposure to the virus. Interpretation & conclusion: This seroprevalence study indicates that large numbers of individuals show exposure to PVB 19 virus. The exposure as indicated by IgG positivity is seen to increase with age. The IgG negative individuals may be considered to be at risk of developing infections due to PVB 19.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalIndian Journal of Medical Research
Volume115
Issue numberAPR.
Publication statusPublished - Apr 1 2002
Externally publishedYes

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Keywords

  • IgG antibodies
  • Parvovirus B 19
  • Pilot study
  • Seroprevalence

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Abraham, M., Rudraraju, R., Kannangai, R., George, K., Cherian, T., Daniel, D., ... Sridharan, G. (2002). A pilot study on the seroprevalence of parvovirus B19 infection. Indian Journal of Medical Research, 115(APR.), 139-143.