A phosphatase associated with metastasis of colorectal cancer

S. Saha, A. Bardelli, P. Buckhaults, Victor E Velculescu, C. Rago, B. St. Croix, K. E. Romans, M. A. Choti, C. Lengauer, Kenneth W Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.

Original languageEnglish (US)
Pages (from-to)1343-1346
Number of pages4
JournalScience
Volume294
Issue number5545
DOIs
StatePublished - Nov 9 2001
Externally publishedYes

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Phosphoric Monoester Hydrolases
Colorectal Neoplasms
Neoplasm Metastasis
Genes
Epithelium
Protein Tyrosine Phosphatases
Transcriptome
Neoplasms
Chromosomes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Saha, S., Bardelli, A., Buckhaults, P., Velculescu, V. E., Rago, C., St. Croix, B., ... Vogelstein, B. (2001). A phosphatase associated with metastasis of colorectal cancer. Science, 294(5545), 1343-1346. https://doi.org/10.1126/science.1065817

A phosphatase associated with metastasis of colorectal cancer. / Saha, S.; Bardelli, A.; Buckhaults, P.; Velculescu, Victor E; Rago, C.; St. Croix, B.; Romans, K. E.; Choti, M. A.; Lengauer, C.; Kinzler, Kenneth W; Vogelstein, Bert.

In: Science, Vol. 294, No. 5545, 09.11.2001, p. 1343-1346.

Research output: Contribution to journalArticle

Saha, S, Bardelli, A, Buckhaults, P, Velculescu, VE, Rago, C, St. Croix, B, Romans, KE, Choti, MA, Lengauer, C, Kinzler, KW & Vogelstein, B 2001, 'A phosphatase associated with metastasis of colorectal cancer', Science, vol. 294, no. 5545, pp. 1343-1346. https://doi.org/10.1126/science.1065817
Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St. Croix B et al. A phosphatase associated with metastasis of colorectal cancer. Science. 2001 Nov 9;294(5545):1343-1346. https://doi.org/10.1126/science.1065817
Saha, S. ; Bardelli, A. ; Buckhaults, P. ; Velculescu, Victor E ; Rago, C. ; St. Croix, B. ; Romans, K. E. ; Choti, M. A. ; Lengauer, C. ; Kinzler, Kenneth W ; Vogelstein, Bert. / A phosphatase associated with metastasis of colorectal cancer. In: Science. 2001 ; Vol. 294, No. 5545. pp. 1343-1346.
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