A perspective on cellular immunity in the elderly

K. V. Khanna, Richard Bryan Markham

Research output: Contribution to journalArticle

Abstract

The increased incidence of infection and malignancy in elderly individuals has prompted many studies that demonstrate that the aging immune system is impaired. Most of these studies have focused on the impairment of acquired immunity provided by lymphocytes. While defects in acquired humoral and T-cell-mediated immunity may exist, increased susceptibility to infection may result from defects in the constitutive functioning of macrophages and granulocytes. Recognition of the potential importance of defects in constitutive immunity in the elderly may provide new opportunities for therapeutic and prophylactic intervention in this population.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalClinical Infectious Diseases
Volume28
Issue number4
StatePublished - 1999

Fingerprint

Cellular Immunity
Adaptive Immunity
Infection
Granulocytes
Immune System
Immunity
Macrophages
Lymphocytes
T-Lymphocytes
Incidence
Population
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

A perspective on cellular immunity in the elderly. / Khanna, K. V.; Markham, Richard Bryan.

In: Clinical Infectious Diseases, Vol. 28, No. 4, 1999, p. 710-713.

Research output: Contribution to journalArticle

@article{512365a1d5984304895b543bcb5955aa,
title = "A perspective on cellular immunity in the elderly",
abstract = "The increased incidence of infection and malignancy in elderly individuals has prompted many studies that demonstrate that the aging immune system is impaired. Most of these studies have focused on the impairment of acquired immunity provided by lymphocytes. While defects in acquired humoral and T-cell-mediated immunity may exist, increased susceptibility to infection may result from defects in the constitutive functioning of macrophages and granulocytes. Recognition of the potential importance of defects in constitutive immunity in the elderly may provide new opportunities for therapeutic and prophylactic intervention in this population.",
author = "Khanna, {K. V.} and Markham, {Richard Bryan}",
year = "1999",
language = "English (US)",
volume = "28",
pages = "710--713",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - A perspective on cellular immunity in the elderly

AU - Khanna, K. V.

AU - Markham, Richard Bryan

PY - 1999

Y1 - 1999

N2 - The increased incidence of infection and malignancy in elderly individuals has prompted many studies that demonstrate that the aging immune system is impaired. Most of these studies have focused on the impairment of acquired immunity provided by lymphocytes. While defects in acquired humoral and T-cell-mediated immunity may exist, increased susceptibility to infection may result from defects in the constitutive functioning of macrophages and granulocytes. Recognition of the potential importance of defects in constitutive immunity in the elderly may provide new opportunities for therapeutic and prophylactic intervention in this population.

AB - The increased incidence of infection and malignancy in elderly individuals has prompted many studies that demonstrate that the aging immune system is impaired. Most of these studies have focused on the impairment of acquired immunity provided by lymphocytes. While defects in acquired humoral and T-cell-mediated immunity may exist, increased susceptibility to infection may result from defects in the constitutive functioning of macrophages and granulocytes. Recognition of the potential importance of defects in constitutive immunity in the elderly may provide new opportunities for therapeutic and prophylactic intervention in this population.

UR - http://www.scopus.com/inward/record.url?scp=0032951779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032951779&partnerID=8YFLogxK

M3 - Article

C2 - 10825023

AN - SCOPUS:0032951779

VL - 28

SP - 710

EP - 713

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 4

ER -