A personalized biomechanical model for respiratory motion prediction

B. Fuerst, T. Mansi, Jianwen Zhang, P. Khurd, J. Declerck, T. Boettger, Nassir Navab, J. Bayouth, Dorin Comaniciu, A. Kamen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations


Time-resolved imaging of the thorax or abdominal area is affected by respiratory motion. Nowadays, one-dimensional respiratory surrogates are used to estimate the current state of the lung during its cycle, but with rather poor results. This paper presents a framework to predict the 3D lung motion based on a patient-specific finite element model of respiratory mechanics estimated from two CT images at end of inspiration (EI) and end of expiration (EE). We first segment the lung, thorax and sub-diaphragm organs automatically using a machine-learning algorithm. Then, a biomechanical model of the lung, thorax and sub-diaphragm is employed to compute the 3D respiratory motion. Our model is driven by thoracic pressures, estimated automatically from the EE and EI images using a trust-region approach. Finally, lung motion is predicted by modulating the thoracic pressures. The effectiveness of our approach is evaluated by predicting lung deformation during exhale on five DIR-Lab datasets. Several personalization strategies are tested, showing that an average error of 3.88 ± 1.54 mm in predicted landmark positions can be achieved. Since our approach is generative, it may constitute a 3D surrogate information for more accurate medical image reconstruction and patient respiratory analysis.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings
EditorsNicholas Ayache, Herve Delingette, Polina Golland, Kensaku Mori
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783642334535
StatePublished - 2012
Externally publishedYes
Event15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012 - Nice, France
Duration: Oct 1 2012Oct 5 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7512 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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