A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH)

Hon Fong L. Mark, Yvonne Mark, Edgar Sotomayor, Sundaresan Sambandam

Research output: Contribution to journalArticle

Abstract

Molecular cytogenetics using fluorescent in situ hybridization (FISH) is an extremely useful adjunct technique to conventional cytogenetics via GTG-banding. The present paper illustrates the utility of FISH by describing a patient with myelodysplastic syndrome (MDS) who was initially studied using GTG-banding and whose bone marrow was found to be populated with hyperdiploid cells. FISH was used to delineate the numerical and structural chromosomal abnormalities. It revealed the presence of trisomy 8 and determined that the previously unidentifiable marker chromosome was of chromosome 10 origin. Although trisomy 8 is a frequent finding in MDS, the structural chromosomal abnormality of chromosome 10 as reported here is not a common finding.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalCytobios
Volume1998
Issue number376
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Myelodysplastic Syndromes
fluorescence in situ hybridization
Fluorescence In Situ Hybridization
chromosome
trisomics
Chromosomes, Human, Pair 10
chromosome aberrations
cytogenetics
abnormality
chromosomes
Cytogenetics
Chromosome Aberrations
Polyploidy
Genetic Markers
polyploidy
bone marrow
bone
Bone Marrow
in situ
cells

Keywords

  • Chromosome 10 marker
  • Fluorescent in situ hybridization
  • GTG-banding
  • Trisomy 8

ASJC Scopus subject areas

  • Aquatic Science
  • Cell Biology

Cite this

Mark, H. F. L., Mark, Y., Sotomayor, E., & Sambandam, S. (1998). A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH). Cytobios, 1998(376), 121-128.

A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH). / Mark, Hon Fong L.; Mark, Yvonne; Sotomayor, Edgar; Sambandam, Sundaresan.

In: Cytobios, Vol. 1998, No. 376, 01.12.1998, p. 121-128.

Research output: Contribution to journalArticle

Mark, HFL, Mark, Y, Sotomayor, E & Sambandam, S 1998, 'A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH)', Cytobios, vol. 1998, no. 376, pp. 121-128.
Mark HFL, Mark Y, Sotomayor E, Sambandam S. A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH). Cytobios. 1998 Dec 1;1998(376):121-128.
Mark, Hon Fong L. ; Mark, Yvonne ; Sotomayor, Edgar ; Sambandam, Sundaresan. / A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH). In: Cytobios. 1998 ; Vol. 1998, No. 376. pp. 121-128.
@article{d55f37d16f4b4759ae6b2d7f4eb69a90,
title = "A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH)",
abstract = "Molecular cytogenetics using fluorescent in situ hybridization (FISH) is an extremely useful adjunct technique to conventional cytogenetics via GTG-banding. The present paper illustrates the utility of FISH by describing a patient with myelodysplastic syndrome (MDS) who was initially studied using GTG-banding and whose bone marrow was found to be populated with hyperdiploid cells. FISH was used to delineate the numerical and structural chromosomal abnormalities. It revealed the presence of trisomy 8 and determined that the previously unidentifiable marker chromosome was of chromosome 10 origin. Although trisomy 8 is a frequent finding in MDS, the structural chromosomal abnormality of chromosome 10 as reported here is not a common finding.",
keywords = "Chromosome 10 marker, Fluorescent in situ hybridization, GTG-banding, Trisomy 8",
author = "Mark, {Hon Fong L.} and Yvonne Mark and Edgar Sotomayor and Sundaresan Sambandam",
year = "1998",
month = "12",
day = "1",
language = "English (US)",
volume = "1998",
pages = "121--128",
journal = "Cytobios",
issn = "0011-4529",
publisher = "University of Cambridge",
number = "376",

}

TY - JOUR

T1 - A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH)

AU - Mark, Hon Fong L.

AU - Mark, Yvonne

AU - Sotomayor, Edgar

AU - Sambandam, Sundaresan

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Molecular cytogenetics using fluorescent in situ hybridization (FISH) is an extremely useful adjunct technique to conventional cytogenetics via GTG-banding. The present paper illustrates the utility of FISH by describing a patient with myelodysplastic syndrome (MDS) who was initially studied using GTG-banding and whose bone marrow was found to be populated with hyperdiploid cells. FISH was used to delineate the numerical and structural chromosomal abnormalities. It revealed the presence of trisomy 8 and determined that the previously unidentifiable marker chromosome was of chromosome 10 origin. Although trisomy 8 is a frequent finding in MDS, the structural chromosomal abnormality of chromosome 10 as reported here is not a common finding.

AB - Molecular cytogenetics using fluorescent in situ hybridization (FISH) is an extremely useful adjunct technique to conventional cytogenetics via GTG-banding. The present paper illustrates the utility of FISH by describing a patient with myelodysplastic syndrome (MDS) who was initially studied using GTG-banding and whose bone marrow was found to be populated with hyperdiploid cells. FISH was used to delineate the numerical and structural chromosomal abnormalities. It revealed the presence of trisomy 8 and determined that the previously unidentifiable marker chromosome was of chromosome 10 origin. Although trisomy 8 is a frequent finding in MDS, the structural chromosomal abnormality of chromosome 10 as reported here is not a common finding.

KW - Chromosome 10 marker

KW - Fluorescent in situ hybridization

KW - GTG-banding

KW - Trisomy 8

UR - http://www.scopus.com/inward/record.url?scp=0031987103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031987103&partnerID=8YFLogxK

M3 - Article

C2 - 9839434

AN - SCOPUS:0031987103

VL - 1998

SP - 121

EP - 128

JO - Cytobios

JF - Cytobios

SN - 0011-4529

IS - 376

ER -