A patient with myelodysplastic syndrome studied by GTG-banding and fluorescent in situ hybridization (FISH)

Hon Fong L. Mark, Yvonne Mark, Edgar Sotomayor, Sundaresan Sambandam

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular cytogenetics using fluorescent in situ hybridization (FISH) is an extremely useful adjunct technique to conventional cytogenetics via GTG-banding. The present paper illustrates the utility of FISH by describing a patient with myelodysplastic syndrome (MDS) who was initially studied using GTG-banding and whose bone marrow was found to be populated with hyperdiploid cells. FISH was used to delineate the numerical and structural chromosomal abnormalities. It revealed the presence of trisomy 8 and determined that the previously unidentifiable marker chromosome was of chromosome 10 origin. Although trisomy 8 is a frequent finding in MDS, the structural chromosomal abnormality of chromosome 10 as reported here is not a common finding.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalCytobios
Volume1998
Issue number376
StatePublished - Dec 1 1998

Keywords

  • Chromosome 10 marker
  • Fluorescent in situ hybridization
  • GTG-banding
  • Trisomy 8

ASJC Scopus subject areas

  • Aquatic Science
  • Cell Biology

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