A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in coma: Causes and consequences of Lactate-protected hypoglycaemia

G. Oldenbeuving, J. R. Mcdonald, Matthew Goodwin, R. Sayilir, D. J. Reijngoud, L. B. Gladden, M. W.N. Nijsten

Research output: Contribution to journalArticle

Abstract

Lactate can substitute for glucose as a metabolic substrate. We report a patient with acute liver failure who was awake despite a glucose level of 0.7 mmol/l with very high lactate level of 25 mmol/l. The hypoglycaemia+hyperlactataemia combination may be considered paradoxical since glucose is the main precursor of lactate and lactate is reconverted into glucose by the Cori cycle. Literature relevant to the under-lying mechanism of combined deep hypoglycaemia and severe hyperlactataemia was assessed. We also assessed the literature for evidence of protection against deep hypoglycaemia by hyperlactataemia. Four syndromes demonstrating hypoglycaemia+hyperlactataemia were found: 1) paracetamol-induced acute liver failure, 2) severe malaria, 3) lymphoma and 4) glucose-6-phosphatase deficiency. An impaired Cori cycle is a key component in all of these metabolic states. Apparently the liver, after exhausting its glycogen stores, loses the gluconeogenic pathway to generate glucose and thereby its ability to remove lactate as well. Several patients with lactic acidosis and glucose levels below 1.7 mmol/l who were not in a coma have been reported. These observations and other data coherently indicate that lactate-protected hypoglycaemia is, at least transiently, a viable state under experimental and clinical conditions. Severe hypoglycaemia+hyperlactataemia reflects failure of the gluconeogenic pathway of lactate metabolism. The existence of lactate-protected hypoglycaemia implies that patients who present with this metabolic state should not automatically be considered to have sustained irreversible brain damage. Moreover, therapies that aim to achieve hypoglycaemia might be feasible with concomitant hyperlactataemia.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalAnaesthesia and Intensive Care
Volume42
Issue number4
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Coma
  • Gluconeogenesis
  • Hyperlactataemia
  • Hypoglycaemia
  • Paracetamol

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

Cite this

Oldenbeuving, G., Mcdonald, J. R., Goodwin, M., Sayilir, R., Reijngoud, D. J., Gladden, L. B., & Nijsten, M. W. N. (2014). A patient with acute liver failure and extreme hypoglycaemia with lactic acidosis who was not in coma: Causes and consequences of Lactate-protected hypoglycaemia. Anaesthesia and Intensive Care, 42(4), 507-511.