A parsimonious model for gene regulation by miRNAs

Sergej Djuranovic, Ali Nahvi, Rachel Green

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) act with the Argonaute family of proteins to regulate target messenger RNAs (mRNAs) posttranscriptionally. SiRNAs typically induce endonucleolytic cleavage of mRNA with near-perfect complementarity. For targets with less complementarity, both translational repression and mRNA destabilization mechanisms have been implicated in miRNA-mediated gene repression, although the timing, coupling, and relative importance of these events have not been determined. Here, we review gene-specific and global approaches that probe miRNA function and mechanism, looking for a unifying model. More systematic analyses of the molecular specificities of the core components coupled with analysis of the relative timing of the different events will ultimately shed light on the mechanism of miRNA-mediated repression.

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalScience
Volume331
Issue number6017
DOIs
StatePublished - Feb 4 2011

ASJC Scopus subject areas

  • General

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