A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell-microenvironment interactions

Robert D. Loberg, Bishoy A. Gayed, Karin B. Olson, Kenneth J. Pienta

Research output: Contribution to journalReview articlepeer-review

Abstract

The plilability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous "hurdle" to overcome in designing novel cancer therapeutics. New targets of therapy are essential if we are to effectively overcome the evasiveness of cancer. The interaction between the tumor cell and the surrounding microenvironment. creates a vicious cycle that perpetuates disease survival and progression. The future of cancer therapy resides in the ability to focus on the recruited and exploited relationships of the cancer cell with the host environment. These therapies target cancer cell growth early and interrupt the vicious cycle that is created by the tumor cells interacting with bone components by inhibiting osteoclasts, osteoblasts, stromal cells, and endothelial cells. They alter the bone microenvironment, creating a hostile "soil" that prevents the "seed" from developing into bone metastases and represent a potential new platform for the development of prostate cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalJournal of cellular biochemistry
Volume96
Issue number3
DOIs
StatePublished - Oct 15 2005
Externally publishedYes

Keywords

  • Bone metastasis
  • Cancer therapy
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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