A palindrome-mediated recurrent translocation with 3

1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21)

Molly Sheridan, Takema Kato, Chad Haldeman-Englert, G. Reza Jalali, Jeff M. Milunsky, Ying Zou, Ruediger Klaes, Georgio Gimelli, Stefania Gimelli, Robert M. Gemmill, Harry A. Drabkin, April M. Hacker, Julia Brown, David Tomkins, Tamim H. Shaikh, Hiroki Kurahashi, Elaine H. Zackai, Beverly S. Emanuel

Research output: Contribution to journalArticle

Abstract

Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11). We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21). There are at least ten prior reports of this translocation, and nearly identical PATRR8 and PATRR22 breakpoints were validated in several of these published cases. PCR analysis of sperm DNA from healthy males indicates that the t(8;22) arises de novo during gametogenesis in some, but not all, individuals. Furthermore, demonstration that de novo PATRR8-to-PATRR11 translocations occur in sperm suggests that palindrome-mediated translocation is a universal mechanism producing chromosomal rearrangements.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalAmerican Journal of Human Genetics
Volume87
Issue number2
DOIs
StatePublished - Aug 13 2010
Externally publishedYes

Fingerprint

Spermatozoa
Gametogenesis
Genetic Translocation
Genomic Instability
Extremities
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A palindrome-mediated recurrent translocation with 3 : 1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21). / Sheridan, Molly; Kato, Takema; Haldeman-Englert, Chad; Jalali, G. Reza; Milunsky, Jeff M.; Zou, Ying; Klaes, Ruediger; Gimelli, Georgio; Gimelli, Stefania; Gemmill, Robert M.; Drabkin, Harry A.; Hacker, April M.; Brown, Julia; Tomkins, David; Shaikh, Tamim H.; Kurahashi, Hiroki; Zackai, Elaine H.; Emanuel, Beverly S.

In: American Journal of Human Genetics, Vol. 87, No. 2, 13.08.2010, p. 209-218.

Research output: Contribution to journalArticle

Sheridan, M, Kato, T, Haldeman-Englert, C, Jalali, GR, Milunsky, JM, Zou, Y, Klaes, R, Gimelli, G, Gimelli, S, Gemmill, RM, Drabkin, HA, Hacker, AM, Brown, J, Tomkins, D, Shaikh, TH, Kurahashi, H, Zackai, EH & Emanuel, BS 2010, 'A palindrome-mediated recurrent translocation with 3: 1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21)', American Journal of Human Genetics, vol. 87, no. 2, pp. 209-218. https://doi.org/10.1016/j.ajhg.2010.07.002
Sheridan, Molly ; Kato, Takema ; Haldeman-Englert, Chad ; Jalali, G. Reza ; Milunsky, Jeff M. ; Zou, Ying ; Klaes, Ruediger ; Gimelli, Georgio ; Gimelli, Stefania ; Gemmill, Robert M. ; Drabkin, Harry A. ; Hacker, April M. ; Brown, Julia ; Tomkins, David ; Shaikh, Tamim H. ; Kurahashi, Hiroki ; Zackai, Elaine H. ; Emanuel, Beverly S. / A palindrome-mediated recurrent translocation with 3 : 1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21). In: American Journal of Human Genetics. 2010 ; Vol. 87, No. 2. pp. 209-218.
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