A paired comparison of two models of experimental retinal ischemia

Peter L. Gehlbach, Richard L. Purple

Research output: Contribution to journalArticlepeer-review

Abstract

Increased intraocular pressure and vascular ligation models are often used in studies of global ocular ischemia. The purpose of this study is to perform a paired comparison of retinal recovery in these paradigms. Our data indicate that ERG b-wave recovery profiles, following identical periods of ischemia, differ significantly between models. We propose that increased intraocular pressure models induce greater retinal injury than vascular ligation models. We suggest that pressure or another aspect of the increased intraocular pressure model induces injury beyond that caused by ischemia alone and caution against direct comparison of results obtained using these two models.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalCurrent Eye Research
Volume13
Issue number8
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Animal model
  • Cat
  • Electroretinogram
  • Intraocular pressure
  • Ischemia/reperfusion
  • Vascular ligation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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