A one‐pot radiosynthesis of [125I]iodoazido photoaffinity labels

Alan A. Wilson, Dimitri E. Grigoriadis, Robert F. Dannals, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one‐pot synthesis gives good radiochemical yields (40–64%) of pure, high specific activity (350–1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

Original languageEnglish (US)
Pages (from-to)1299-1305
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume27
Issue number11
DOIs
StatePublished - Nov 1989

Keywords

  • I
  • dopamine
  • photoaffinity label
  • radioiodination
  • receptors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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