A one‐pot radiosynthesis of [125I]iodoazido photoaffinity labels

Alan A. Wilson; Dimitri E. Grigoriadis; Robert F. Dannals; Hayden T. Ravert; Henry N. Wagner

doi:10.1002/jlcr.2580271109

A one‐pot radiosynthesis of [¹²⁵I]iodoazido photoaffinity labels

Alan A. Wilson, Dimitri E. Grigoriadis, Robert F. Dannals, Hayden T. Ravert, Henry N. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one‐pot synthesis gives good radiochemical yields (40–64%) of pure, high specific activity (350–1500 mCi/μmol) ¹²⁵I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [¹²⁵I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

Original language	English (US)
Pages (from-to)	1299-1305
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	27
Issue number	11
DOIs	https://doi.org/10.1002/jlcr.2580271109
State	Published - Nov 1989

Keywords

I
dopamine
photoaffinity label
radioiodination
receptors

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580271109

Cite this

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abstract = "A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one‐pot synthesis gives good radiochemical yields (40–64%) of pure, high specific activity (350–1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.",

keywords = "I, dopamine, photoaffinity label, radioiodination, receptors",

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AU - Grigoriadis, Dimitri E.

AU - Dannals, Robert F.

AU - Ravert, Hayden T.

AU - Wagner, Henry N.

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KW - receptors

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