A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels

A. A. Wilson, D. E. Grigoriadis, Robert F Dannals, H. T. Ravert, H. N. Wagner

Research output: Contribution to journalArticle

Abstract

A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64%) of pure, high specific activity (350-1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

Original languageEnglish (US)
Pages (from-to)1299-1305
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume27
Issue number11
StatePublished - 1989

Fingerprint

Photoaffinity Labels
Aniline Compounds
Radioactive materials
Azides
High performance liquid chromatography
Purification
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Wilson, A. A., Grigoriadis, D. E., Dannals, R. F., Ravert, H. T., & Wagner, H. N. (1989). A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels. Journal of Labelled Compounds and Radiopharmaceuticals, 27(11), 1299-1305.

A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels. / Wilson, A. A.; Grigoriadis, D. E.; Dannals, Robert F; Ravert, H. T.; Wagner, H. N.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 27, No. 11, 1989, p. 1299-1305.

Research output: Contribution to journalArticle

Wilson, AA, Grigoriadis, DE, Dannals, RF, Ravert, HT & Wagner, HN 1989, 'A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 27, no. 11, pp. 1299-1305.
Wilson, A. A. ; Grigoriadis, D. E. ; Dannals, Robert F ; Ravert, H. T. ; Wagner, H. N. / A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1989 ; Vol. 27, No. 11. pp. 1299-1305.
@article{75a14b05d7004fdb8b65ccac3da44263,
title = "A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels",
abstract = "A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64{\%}) of pure, high specific activity (350-1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.",
author = "Wilson, {A. A.} and Grigoriadis, {D. E.} and Dannals, {Robert F} and Ravert, {H. T.} and Wagner, {H. N.}",
year = "1989",
language = "English (US)",
volume = "27",
pages = "1299--1305",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

TY - JOUR

T1 - A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels

AU - Wilson, A. A.

AU - Grigoriadis, D. E.

AU - Dannals, Robert F

AU - Ravert, H. T.

AU - Wagner, H. N.

PY - 1989

Y1 - 1989

N2 - A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64%) of pure, high specific activity (350-1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

AB - A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offers significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64%) of pure, high specific activity (350-1500 mCi/μmol) 125I labelled iodoaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography.

UR - http://www.scopus.com/inward/record.url?scp=0024420575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024420575&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0024420575

VL - 27

SP - 1299

EP - 1305

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 11

ER -