A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy

Katherine E. Poruk, Joseph A. Lin, Michol A. Cooper, Jin He, Martin A Makary, Kenzo Hirose, John L Cameron, Timothy M. Pawlik, Christopher Wolfgang, Frederic Eckhauser, Matthew J Weiss

Research output: Contribution to journalArticle

Abstract

Background Although pancreaticoduodenectomy (PD) outcomes have improved, complications including surgical site infection (SSI) remain common. We present a stratification tool to predict risk for SSI after PD. Methods Data was retrospectively reviewed on all patients undergoing PD at a tertiary hospital (9/2011-8/2014). Potential SSI risk factors identified by univariate analysis were incorporated into a multivariate logistic regression model. The resulting odds ratios were converted into a point system to create an SSI risk score with internal validation. Results Six hundred seventy nine patients underwent PD and were chronologically split into derivation (443 patients) and validation (236 patients) groups. There was no difference in demographics or perioperative outcomes between groups. Overall thirty-day SSI was observed in 17.2% (n = 117). Neoadjuvant chemotherapy and/or radiation, intraoperative red blood cell transfusion, operative time greater than 7 h, preoperative bile stent/drain, and vascular resection were associated with SSI in univariate analysis (all p < 0.05). On multivariate analysis, preoperative bile stent/drain and neoadjuvant chemotherapy were independent predictors of SSI, each assigned 1 point (both p < 0.001). Patients with 0, 1, and 2 points, respectively, had 0%, 32%, and 64% predicted risk of SSI (AUC = 0.73, R2 = 0.93). The model performed equivalently in the validation group (AUC = 0.77, R2 = 0.99). Conclusion This novel, validated risk score accurately predicts SSI risk after pancreaticoduodenectomy. Identifying the highest risk patients can help target interventions to reduce SSI.

Original languageEnglish (US)
Pages (from-to)893-899
Number of pages7
JournalHPB
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2016

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Surgical Wound Infection
Pancreaticoduodenectomy
Bile
Area Under Curve
Stents
Logistic Models
Drug Therapy
Erythrocyte Transfusion
Operative Time
Tertiary Care Centers
Blood Vessels
Multivariate Analysis
Odds Ratio
Demography
Radiation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy. / Poruk, Katherine E.; Lin, Joseph A.; Cooper, Michol A.; He, Jin; Makary, Martin A; Hirose, Kenzo; Cameron, John L; Pawlik, Timothy M.; Wolfgang, Christopher; Eckhauser, Frederic; Weiss, Matthew J.

In: HPB, Vol. 18, No. 11, 01.11.2016, p. 893-899.

Research output: Contribution to journalArticle

Poruk, Katherine E. ; Lin, Joseph A. ; Cooper, Michol A. ; He, Jin ; Makary, Martin A ; Hirose, Kenzo ; Cameron, John L ; Pawlik, Timothy M. ; Wolfgang, Christopher ; Eckhauser, Frederic ; Weiss, Matthew J. / A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy. In: HPB. 2016 ; Vol. 18, No. 11. pp. 893-899.
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abstract = "Background Although pancreaticoduodenectomy (PD) outcomes have improved, complications including surgical site infection (SSI) remain common. We present a stratification tool to predict risk for SSI after PD. Methods Data was retrospectively reviewed on all patients undergoing PD at a tertiary hospital (9/2011-8/2014). Potential SSI risk factors identified by univariate analysis were incorporated into a multivariate logistic regression model. The resulting odds ratios were converted into a point system to create an SSI risk score with internal validation. Results Six hundred seventy nine patients underwent PD and were chronologically split into derivation (443 patients) and validation (236 patients) groups. There was no difference in demographics or perioperative outcomes between groups. Overall thirty-day SSI was observed in 17.2{\%} (n = 117). Neoadjuvant chemotherapy and/or radiation, intraoperative red blood cell transfusion, operative time greater than 7 h, preoperative bile stent/drain, and vascular resection were associated with SSI in univariate analysis (all p < 0.05). On multivariate analysis, preoperative bile stent/drain and neoadjuvant chemotherapy were independent predictors of SSI, each assigned 1 point (both p < 0.001). Patients with 0, 1, and 2 points, respectively, had 0{\%}, 32{\%}, and 64{\%} predicted risk of SSI (AUC = 0.73, R2 = 0.93). The model performed equivalently in the validation group (AUC = 0.77, R2 = 0.99). Conclusion This novel, validated risk score accurately predicts SSI risk after pancreaticoduodenectomy. Identifying the highest risk patients can help target interventions to reduce SSI.",
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T1 - A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy

AU - Poruk, Katherine E.

AU - Lin, Joseph A.

AU - Cooper, Michol A.

AU - He, Jin

AU - Makary, Martin A

AU - Hirose, Kenzo

AU - Cameron, John L

AU - Pawlik, Timothy M.

AU - Wolfgang, Christopher

AU - Eckhauser, Frederic

AU - Weiss, Matthew J

PY - 2016/11/1

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N2 - Background Although pancreaticoduodenectomy (PD) outcomes have improved, complications including surgical site infection (SSI) remain common. We present a stratification tool to predict risk for SSI after PD. Methods Data was retrospectively reviewed on all patients undergoing PD at a tertiary hospital (9/2011-8/2014). Potential SSI risk factors identified by univariate analysis were incorporated into a multivariate logistic regression model. The resulting odds ratios were converted into a point system to create an SSI risk score with internal validation. Results Six hundred seventy nine patients underwent PD and were chronologically split into derivation (443 patients) and validation (236 patients) groups. There was no difference in demographics or perioperative outcomes between groups. Overall thirty-day SSI was observed in 17.2% (n = 117). Neoadjuvant chemotherapy and/or radiation, intraoperative red blood cell transfusion, operative time greater than 7 h, preoperative bile stent/drain, and vascular resection were associated with SSI in univariate analysis (all p < 0.05). On multivariate analysis, preoperative bile stent/drain and neoadjuvant chemotherapy were independent predictors of SSI, each assigned 1 point (both p < 0.001). Patients with 0, 1, and 2 points, respectively, had 0%, 32%, and 64% predicted risk of SSI (AUC = 0.73, R2 = 0.93). The model performed equivalently in the validation group (AUC = 0.77, R2 = 0.99). Conclusion This novel, validated risk score accurately predicts SSI risk after pancreaticoduodenectomy. Identifying the highest risk patients can help target interventions to reduce SSI.

AB - Background Although pancreaticoduodenectomy (PD) outcomes have improved, complications including surgical site infection (SSI) remain common. We present a stratification tool to predict risk for SSI after PD. Methods Data was retrospectively reviewed on all patients undergoing PD at a tertiary hospital (9/2011-8/2014). Potential SSI risk factors identified by univariate analysis were incorporated into a multivariate logistic regression model. The resulting odds ratios were converted into a point system to create an SSI risk score with internal validation. Results Six hundred seventy nine patients underwent PD and were chronologically split into derivation (443 patients) and validation (236 patients) groups. There was no difference in demographics or perioperative outcomes between groups. Overall thirty-day SSI was observed in 17.2% (n = 117). Neoadjuvant chemotherapy and/or radiation, intraoperative red blood cell transfusion, operative time greater than 7 h, preoperative bile stent/drain, and vascular resection were associated with SSI in univariate analysis (all p < 0.05). On multivariate analysis, preoperative bile stent/drain and neoadjuvant chemotherapy were independent predictors of SSI, each assigned 1 point (both p < 0.001). Patients with 0, 1, and 2 points, respectively, had 0%, 32%, and 64% predicted risk of SSI (AUC = 0.73, R2 = 0.93). The model performed equivalently in the validation group (AUC = 0.77, R2 = 0.99). Conclusion This novel, validated risk score accurately predicts SSI risk after pancreaticoduodenectomy. Identifying the highest risk patients can help target interventions to reduce SSI.

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