A novel therapeutic for refractory chylothorax

Douglas Z. Liou, Heather Warren, Dermot P. Maher, Harmik J. Soukiasian, Nicolas Melo, Ali Salim, Eric J. Ley

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modifi cation, or aggressive surgical interventions such as thoracic duct ligation, fl ap coverage, fi brin glue, or talc pleurodesis; few successful medical therapeutics are available. We report a case of a high-output chylothorax refractory to aggressive medical and surgical interventions. Chyle output decreased substantially after initiating midodrine, an α1-adrenergic agonist that causes vasoconstriction of the lymph system, reducing chyle fl ow. This case report suggests that midodrine may be a novel therapeutic for refractory chyle leaks.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
Issue number3
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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