A novel spectrally selective fat saturation pulse design with robustness to B0 and B1 inhomogeneities: A demonstration on 3D T1-weighted breast MRI at 3 T

Research output: Contribution to journalArticlepeer-review


Purpose: Spectrally selective fat saturation (FatSat) sequence is commonly used to suppress signal from adipose tissue. Conventional SINC-shaped pulses are sensitive to B0 off-resonance and B1+ offset. Uniform fat saturation with large spatial coverage is especially challenging for the body and breast MRI. The aim of this study is to develop spectrally selective FatSat pulses that offer more immunity to B0/B1+ field inhomogeneities than SINC pulses and evaluate them in bilateral breast imaging at 3 T. Materials and methods: Optimized composite pulses (OCP) were designed based on the optimal control theory with robustness to a targeted B0/ B1+ conditions. OCP pulses also allows flexible flip angles to meet different requirements. Comparisons with the vendor-provided SINC pulses were conducted by numerical simulation and in vivo scans using a 3D T1-weighted (T1w) gradient-echo (GRE) sequence with coverage of the whole-breast. Results: Simulation revealed that OCP pulses yielded almost half of the transition band and much less sensitivity to B1+ inhomogeneity compared to SINC pulses with B0 off-resonance within ±200 Hz and B1+ scale error within ±0.3 (P < 0.001). Across five normal subjects, OCP FatSat pulses produced 25–41% lower residual fat signals (P < 0.05) with 27–36% less spatial variation (P < 0.05) than SINC. Conclusion: In contrast to conventional SINC-shaped pulses, the newly designed OCP FatSat pulses mitigated challenges of wide range of B0/ B1+ field inhomogeneities and achieved more uniform fat suppression in bilateral breast T1w imaging at 3 T.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalMagnetic Resonance Imaging
StatePublished - Jan 2021


  • B insensitive
  • B insensitive
  • Breast MRI
  • Fat saturation
  • Fat suppression
  • Optimal control
  • Spectrally selective RF pulse

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'A novel spectrally selective fat saturation pulse design with robustness to B<sub>0</sub> and B<sub>1</sub> inhomogeneities: A demonstration on 3D T<sub>1</sub>-weighted breast MRI at 3 T'. Together they form a unique fingerprint.

Cite this