A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina

Ed Soucy, Yanshu Wang, Sheila Nirenberg, Jeremy Nathans, Markus Meister

Research output: Contribution to journalArticlepeer-review

Abstract

Current understanding suggests that mammalian rod photoreceptors connect only to an ON-type bipolar cell. This rod-specific bipolar cell excites the All amacrine cell, which makes connections to cone-specific bipolar cells of both ON and OFF type; these, in turn, synapse with ganglion cells. Recent work on rabbit retina has shown that rod signals can also reach ganglion cells without passing through the rod bipolar cell. This route was thought to be provided by electrical gap junctions, through which rods signal directly to cones and thence to cone bipolar cells. Here, we show that the mouse retina also provides a rod pathway bypassing the rod bipolar cell, suggesting that this is a common feature in mammals. However, this alternative pathway does not require cone photoreceptors; it is perfectly intact in a transgenic mouse whose retina lacks cones. Instead, the results can be explained if rods connect directly to OFF bipolar cells.

Original languageEnglish (US)
Pages (from-to)481-493
Number of pages13
JournalNeuron
Volume21
Issue number3
DOIs
StatePublished - Sep 1998

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina'. Together they form a unique fingerprint.

Cite this