TY - JOUR
T1 - A novel role for hGas7b in microtubular maintenance
T2 - Possible implication in Tau-associated pathology in Alzheimer disease
AU - Akiyama, Hirotada
AU - Gotoh, Aina
AU - Shin, Ryong Woon
AU - Koga, Tomoe
AU - Ohashi, Tsubasa
AU - Sakamoto, Wataru
AU - Harada, Akihiro
AU - Arai, Hiroyuki
AU - Sawa, Akira
AU - Uchida, Chiyoko
AU - Uchida, Takafumi
PY - 2009/11/20
Y1 - 2009/11/20
N2 - Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptidyl prolyl cis/trans isomerase, Pin1, that facilitates microtubule assembly. Thus, we have demonstrated that hGas7b binds Tau at the WW motif and that the hGas7b/Tau protein complex interacts with the microtubules, promoting tubulin polymerization. Tau, in turn, contributes to protein stability of hGas7b. Furthermore, we observed decreased levels of hGas7b in the brains from patients with Alzheimer disease. These results suggest an important role for hGas7b in microtubular maintenance and possible implication in Alzheimer disease.
AB - Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptidyl prolyl cis/trans isomerase, Pin1, that facilitates microtubule assembly. Thus, we have demonstrated that hGas7b binds Tau at the WW motif and that the hGas7b/Tau protein complex interacts with the microtubules, promoting tubulin polymerization. Tau, in turn, contributes to protein stability of hGas7b. Furthermore, we observed decreased levels of hGas7b in the brains from patients with Alzheimer disease. These results suggest an important role for hGas7b in microtubular maintenance and possible implication in Alzheimer disease.
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U2 - 10.1074/jbc.M109.035998
DO - 10.1074/jbc.M109.035998
M3 - Article
C2 - 19801671
AN - SCOPUS:70450255112
SN - 0021-9258
VL - 284
SP - 32695
EP - 32699
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 47
ER -