A Novel Role for a Familiar Protein in Apoptosis Induced by Proteasome Inhibition

Research output: Contribution to journalShort survey


In this issue of Cancer Cell, Nickeleit et al. (2008) identify a new proteasome inhibitor, argyrin A, and show that it induces apoptosis and inhibits angiogenesis via p27-dependent mechanisms. Their observations challenge current thinking about how this class of promising cancer therapies works and why they selectively kill cancer cells.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalCancer Cell
Issue number1
Publication statusPublished - Jul 8 2008
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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