A novel radioligand for imaging the AT1 angiotensin receptor with PET

William B Mathews, Sung Eun Yoo, Sung Hou Lee, Ursula Scheffel, Paige A. Rauseo, Tamas G. Zober, Gerard Gocco, Kathryn Sandberg, Hayden T. Ravert, Robert F Dannals, Zsolt Szabo

Research output: Contribution to journalArticle

Abstract

2-Butyl-5-methoxymethyl-6-(1-oxopyridin-2-yl)-3-[[2′-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (KR31173) was radiolabeled by coupling a tetrazole-protected hydroxy precursor with [11C] methyl iodide and removing the protecting group by acid hydrolysis. In mice, the highest uptake of [11C] KR31173 was in the adrenal glands, kidneys, and liver. Tissue to blood ratios were generally greater than 10:1. Uptake of the tracer in the adrenal glands, kidneys, lungs, and heart was blocked with a 1 mg/kg dose of KR31173 or MK-996.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalNuclear Medicine and Biology
Volume31
Issue number5
DOIs
StatePublished - Jul 2004

Fingerprint

Angiotensin Type 1 Receptor
MK 996
Adrenal Glands
Kidney
Hydrolysis
Lung
Acids
Liver
diphenyl
1H-tetrazole
methyl iodide
2-butyl-5-methoxymethyl-6-(1-oxopyridin-2-yl)-3-((2'-(1H-tetrazol-5-yl)bipohenyl-4-yl)methyl)-3H-imidazo(4,5-b)pyridine
imidazo(4,5-b)pyridine

Keywords

  • Angiotensin
  • AT
  • Hypertension
  • KR31173
  • Mice
  • PET

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

A novel radioligand for imaging the AT1 angiotensin receptor with PET. / Mathews, William B; Yoo, Sung Eun; Lee, Sung Hou; Scheffel, Ursula; Rauseo, Paige A.; Zober, Tamas G.; Gocco, Gerard; Sandberg, Kathryn; Ravert, Hayden T.; Dannals, Robert F; Szabo, Zsolt.

In: Nuclear Medicine and Biology, Vol. 31, No. 5, 07.2004, p. 571-574.

Research output: Contribution to journalArticle

Mathews, WB, Yoo, SE, Lee, SH, Scheffel, U, Rauseo, PA, Zober, TG, Gocco, G, Sandberg, K, Ravert, HT, Dannals, RF & Szabo, Z 2004, 'A novel radioligand for imaging the AT1 angiotensin receptor with PET', Nuclear Medicine and Biology, vol. 31, no. 5, pp. 571-574. https://doi.org/10.1016/j.nucmedbio.2003.10.014
Mathews, William B ; Yoo, Sung Eun ; Lee, Sung Hou ; Scheffel, Ursula ; Rauseo, Paige A. ; Zober, Tamas G. ; Gocco, Gerard ; Sandberg, Kathryn ; Ravert, Hayden T. ; Dannals, Robert F ; Szabo, Zsolt. / A novel radioligand for imaging the AT1 angiotensin receptor with PET. In: Nuclear Medicine and Biology. 2004 ; Vol. 31, No. 5. pp. 571-574.
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AU - Gocco, Gerard

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