A novel quantitative EEG injury measure of global cerebral ischemia

R. G. Geocadin, R. Ghodadra, T. Kimura, H. Lei, D. L. Sherman, D. F. Hanley, N. V. Thakor

Research output: Contribution to journalArticle

Abstract

Objective: To develop a novel quantitative EEG (qEEG) based analysis method, cepstral distance (CD) and compare it to spectral distance (SD) in detecting EEG changes related to global ischemia in rats. Methods: Adult Wistar rats were subjected to asphyxic-cardiac arrest for sham, 1, 3, 5 and 7 min (n = 5 per group). The EEG signal was processed and fitted into an autoregressive (AR) model. A pre-injury baseline EEG was compared to selected data segments during asphyxia and recovery. The dissimilarities in the EEG segments were measured using CD and SD. A segment measured was considered abnormal when it exceeded 30% of baseline and its duration was used as the index of injury. A comprehensive Neurodeficit Score (NDS) at 24 h was used to assess outcome and was correlated with CD and SD measures. Results: A higher correlation was found with CD and asphyxia time (r = 0.81, P < 0.001) compared to SD and asphyxia time (r = 0.69, P < 0.001). Correlation with cardiac arrest time (MAP < 10 mmHg) showed that CD was superior (r = 0.71, P < 0.001) to SD (r = 0.52, P = 0.002). CD obtained during global ischemia and 90 min into recovery correlated significantly with NDS at 24 h after injury (Spearman coefficient = -0.83, P < 0.005), and was more robust than the traditional SD (Spearman coefficient = -0.63, P < 0.005). Conclusion: The novel qEEG-based injury index from CD was superior to SD in quantifying early cerebral dysfunction after cardiac arrest and in providing neurological prognosis at 24 h after global ischemia in adult rats. Studying early qEEG changes after asphyxic-cardiac arrest may provide new insights into the injury and recovery process, and present opportunities for therapy. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)1779-1787
Number of pages9
JournalClinical Neurophysiology
Volume111
Issue number10
DOIs
StatePublished - Oct 1 2000

Keywords

  • Asphyxia
  • Global ischemia
  • Neurological outcome
  • Prognosis
  • Quantitative EEG

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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