A novel prostate cancer susceptibility locus at 19q13

Fang Chi Hsu, Jielin Sun, Fredrik Wiklund, Sarah D. Isaacs, Kathleen E. Wiley, Lina D. Purcell, Zhengrong Gao, Par Stattin, Yi Zhu, Seong Tae Kim, Zheng Zhang, Wennuan Liu, Bao Li Chang, Patrick Walsh, David Duggan, John D. Carpten, William B Isaacs, Henrik Grönberg, Jianfeng Xu, S. Lilly Zheng

Research output: Contribution to journalArticle

Abstract

A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNFs where the frequency of the risk allele was consistently higher in cases than in controls in each of the five CGEMS study populations. Genotype information for 22 of these 43 SNPs was obtained either directly by genotyping or indirectly by imputation in our PCa GWAS of 500 cases and 500 controls selected from a population-based case-control study in Sweden [Cancer of the Prostate in Sweden (CAPS)]. Two of these 22 SNPs were significantly associated with PCa risk (P <0.05). We then genotyped these two SNPs in the remaining cases (n = 2,393) and controls (n = 1,222) from CAPS and found that rs887391 at 19ql3 was highly associated with PCa risk (P = 9.4 x 10-4). A similar trend of association was found for this SNP in a case-control study from Johns Hopkins Hospital (JHH), albeit the result was not statistically significant. Altogether, the frequency of the risk allele of rs887391 was consistently higher in cases than controls among each of seven study populations examined, with an overall P = 3.2 x 10 7 from a combined allelic test. A fine-mapping study in a 110-kb region at 19q13 among CAPS and JHH study. populations revealed that rs887391 was the most strongly associated SNP in the region. Additional confirmation studies of this region are warranted,

Original languageEnglish (US)
Pages (from-to)2720-2723
Number of pages4
JournalCancer Research
Volume69
Issue number7
DOIs
StatePublished - Apr 1 2009

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Prostatic Neoplasms
Single Nucleotide Polymorphism
Sweden
Genome-Wide Association Study
Genetic Predisposition to Disease
Genetic Markers
Gene Frequency
Population
Case-Control Studies
Neoplasms
Genotype
Genome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hsu, F. C., Sun, J., Wiklund, F., Isaacs, S. D., Wiley, K. E., Purcell, L. D., ... Zheng, S. L. (2009). A novel prostate cancer susceptibility locus at 19q13. Cancer Research, 69(7), 2720-2723. https://doi.org/10.1158/0008-5472.CAN-08-3347

A novel prostate cancer susceptibility locus at 19q13. / Hsu, Fang Chi; Sun, Jielin; Wiklund, Fredrik; Isaacs, Sarah D.; Wiley, Kathleen E.; Purcell, Lina D.; Gao, Zhengrong; Stattin, Par; Zhu, Yi; Kim, Seong Tae; Zhang, Zheng; Liu, Wennuan; Chang, Bao Li; Walsh, Patrick; Duggan, David; Carpten, John D.; Isaacs, William B; Grönberg, Henrik; Xu, Jianfeng; Zheng, S. Lilly.

In: Cancer Research, Vol. 69, No. 7, 01.04.2009, p. 2720-2723.

Research output: Contribution to journalArticle

Hsu, FC, Sun, J, Wiklund, F, Isaacs, SD, Wiley, KE, Purcell, LD, Gao, Z, Stattin, P, Zhu, Y, Kim, ST, Zhang, Z, Liu, W, Chang, BL, Walsh, P, Duggan, D, Carpten, JD, Isaacs, WB, Grönberg, H, Xu, J & Zheng, SL 2009, 'A novel prostate cancer susceptibility locus at 19q13', Cancer Research, vol. 69, no. 7, pp. 2720-2723. https://doi.org/10.1158/0008-5472.CAN-08-3347
Hsu FC, Sun J, Wiklund F, Isaacs SD, Wiley KE, Purcell LD et al. A novel prostate cancer susceptibility locus at 19q13. Cancer Research. 2009 Apr 1;69(7):2720-2723. https://doi.org/10.1158/0008-5472.CAN-08-3347
Hsu, Fang Chi ; Sun, Jielin ; Wiklund, Fredrik ; Isaacs, Sarah D. ; Wiley, Kathleen E. ; Purcell, Lina D. ; Gao, Zhengrong ; Stattin, Par ; Zhu, Yi ; Kim, Seong Tae ; Zhang, Zheng ; Liu, Wennuan ; Chang, Bao Li ; Walsh, Patrick ; Duggan, David ; Carpten, John D. ; Isaacs, William B ; Grönberg, Henrik ; Xu, Jianfeng ; Zheng, S. Lilly. / A novel prostate cancer susceptibility locus at 19q13. In: Cancer Research. 2009 ; Vol. 69, No. 7. pp. 2720-2723.
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AU - Gao, Zhengrong

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AU - Chang, Bao Li

AU - Walsh, Patrick

AU - Duggan, David

AU - Carpten, John D.

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