A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Weidong Wu; Caren L.Freel Meyers; Richard F. Borch

doi:10.1021/ol049267j

A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Weidong Wu, Caren L.Freel Meyers, Richard F. Borch

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

Original language	English (US)
Pages (from-to)	2257-2260
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	13
DOIs	https://doi.org/10.1021/ol049267j
State	Published - Jun 24 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol049267j

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title = "A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates",

abstract = "A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.",

author = "Weidong Wu and Meyers, {Caren L.Freel} and Borch, {Richard F.}",

year = "2004",

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doi = "10.1021/ol049267j",

language = "English (US)",

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AU - Meyers, Caren L.Freel

AU - Borch, Richard F.

PY - 2004/6/24

Y1 - 2004/6/24

N2 - A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

AB - A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

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JO - Organic Letters

JF - Organic Letters

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ER -

A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Abstract

ASJC Scopus subject areas

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