A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

Weidong Wu, Caren L.Freel Meyers, Richard F. Borch

Research output: Contribution to journalArticle

Abstract

A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

Original languageEnglish (US)
Pages (from-to)2257-2260
Number of pages4
JournalOrganic Letters
Volume6
Issue number13
DOIs
StatePublished - Jun 24 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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