TY - JOUR
T1 - A novel method for determining the inhibitory potential of anti-HIV drugs
AU - Shen, Lin
AU - Rabi, S. Alireza
AU - Siliciano, Robert F.
N1 - Funding Information:
This work was supported by NIH grant RO1 AI081600 and by the Howard Hughes Medical Institute.
PY - 2009/12
Y1 - 2009/12
N2 - In the absence of cure, most HIV-1-infected individuals will require lifelong treatment. It is therefore essential to optimize highly active antiretroviral therapy. Recent research has shown that the slope parameter or Hill coefficient, which describes the steepness of a dose-response curve, is a critical missing dimension in the evaluation of the activity of antiviral drugs. Based on this finding, instantaneous inhibitory potential (IIP) has been derived as a new measure of antiviral drug activity. IIP incorporates the slope parameter and thus is a more accurate pharmacodynamic measure of antiviral activity than current measures such as IC50 and inhibitory quotient. Determining how to use IIP to predict the in vivo efficacy of anti-HIV-1 drugs is nevertheless important. This article discusses recent advances in in vitro measures of antiviral activity and the therapeutic implications of the dose-response curve slope and IIP.
AB - In the absence of cure, most HIV-1-infected individuals will require lifelong treatment. It is therefore essential to optimize highly active antiretroviral therapy. Recent research has shown that the slope parameter or Hill coefficient, which describes the steepness of a dose-response curve, is a critical missing dimension in the evaluation of the activity of antiviral drugs. Based on this finding, instantaneous inhibitory potential (IIP) has been derived as a new measure of antiviral drug activity. IIP incorporates the slope parameter and thus is a more accurate pharmacodynamic measure of antiviral activity than current measures such as IC50 and inhibitory quotient. Determining how to use IIP to predict the in vivo efficacy of anti-HIV-1 drugs is nevertheless important. This article discusses recent advances in in vitro measures of antiviral activity and the therapeutic implications of the dose-response curve slope and IIP.
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U2 - 10.1016/j.tips.2009.09.003
DO - 10.1016/j.tips.2009.09.003
M3 - Article
C2 - 19837466
AN - SCOPUS:70449633111
SN - 0165-6147
VL - 30
SP - 610
EP - 616
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 12
ER -