A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study

Nader Bakheet; Hee Kyong Na; Jung Hoon Park; Dae sung Ryu; Jae Yong Jeon; Mouen A. Khashab; Vivek Kumbhari; Jiaywei Tsauo; Ho Young Song; Hong Tao Hu; Do Hoon Kim; Hwoon Yong Jung

doi:10.1007/s11695-020-04930-5

A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study

Nader Bakheet, Hee Kyong Na, Jung Hoon Park, Dae sung Ryu, Jae Yong Jeon, Mouen A. Khashab, Vivek Kumbhari, Jiaywei Tsauo, Ho Young Song, Hong Tao Hu, Do Hoon Kim, Hwoon Yong Jung

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aims: Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs. Methods: The intragastric satiety-inducing device (ISD) comprises a self-expandable esophageal metal stent connected to a star-shaped disc placed in the stomach fundus. Eight juvenile pigs were randomized into ISD (n = 5) and control (n = 3) groups. Body weight and serum ghrelin hormone were monitored weekly for 6 weeks. One pig was followed up for 4 additional weeks (rebound pig) after ISD removal. Histological examination and immunohistochemistry for the interstitial cells of Cajal (ICCs) were performed. Results: ISD placement was successful in all pigs. Two ISDs (40%) migrated at 4 and 5 weeks after placement. Weight gain rates were significantly lower in the ISD group than in the control group from week 1 to 6 but were higher in the rebound pig than in a control pig from week 7 to 10. Mean ghrelin hormone level was higher in the control group than in the ISD group from week 1 to 6. ISD induced reversible inflammatory changes in the esophagus and stomach fundus. The number of ICCs was lesser in ISD pigs than in control and rebound pigs. Conclusions: ISD placement is feasible and safe in juvenile pigs. It decreases weight gain rate but induces reversible inflammatory reaction and tissue hyperplasia. Its mechanism may be related to pressure exertion on the stomach fundus or gastric motility alteration.

Original language	English (US)
Pages (from-to)	4643-4651
Number of pages	9
Journal	Obesity Surgery
Volume	30
Issue number	11
DOIs	https://doi.org/10.1007/s11695-020-04930-5
State	Published - Nov 1 2020

Keywords

Interstitial cells of Cajal
Obesity
Self-expandable metallic stents

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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10.1007/s11695-020-04930-5

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@article{22088c122db14d92b4c1400b967925a1,

title = "A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study",

abstract = "Background and Aims: Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs. Methods: The intragastric satiety-inducing device (ISD) comprises a self-expandable esophageal metal stent connected to a star-shaped disc placed in the stomach fundus. Eight juvenile pigs were randomized into ISD (n = 5) and control (n = 3) groups. Body weight and serum ghrelin hormone were monitored weekly for 6 weeks. One pig was followed up for 4 additional weeks (rebound pig) after ISD removal. Histological examination and immunohistochemistry for the interstitial cells of Cajal (ICCs) were performed. Results: ISD placement was successful in all pigs. Two ISDs (40%) migrated at 4 and 5 weeks after placement. Weight gain rates were significantly lower in the ISD group than in the control group from week 1 to 6 but were higher in the rebound pig than in a control pig from week 7 to 10. Mean ghrelin hormone level was higher in the control group than in the ISD group from week 1 to 6. ISD induced reversible inflammatory changes in the esophagus and stomach fundus. The number of ICCs was lesser in ISD pigs than in control and rebound pigs. Conclusions: ISD placement is feasible and safe in juvenile pigs. It decreases weight gain rate but induces reversible inflammatory reaction and tissue hyperplasia. Its mechanism may be related to pressure exertion on the stomach fundus or gastric motility alteration.",

keywords = "Interstitial cells of Cajal, Obesity, Self-expandable metallic stents",

author = "Nader Bakheet and Na, {Hee Kyong} and Park, {Jung Hoon} and Ryu, {Dae sung} and Jeon, {Jae Yong} and Khashab, {Mouen A.} and Vivek Kumbhari and Jiaywei Tsauo and Song, {Ho Young} and Hu, {Hong Tao} and Kim, {Do Hoon} and Jung, {Hwoon Yong}",

note = "Funding Information: This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.) as well as by a grant (2016-7017) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea. Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2020",

month = nov,

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doi = "10.1007/s11695-020-04930-5",

language = "English (US)",

volume = "30",

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TY - JOUR

T1 - A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs

T2 - a Pilot Study

AU - Bakheet, Nader

AU - Na, Hee Kyong

AU - Park, Jung Hoon

AU - Ryu, Dae sung

AU - Jeon, Jae Yong

AU - Khashab, Mouen A.

AU - Kumbhari, Vivek

AU - Tsauo, Jiaywei

AU - Song, Ho Young

AU - Hu, Hong Tao

AU - Kim, Do Hoon

AU - Jung, Hwoon Yong

N1 - Funding Information: This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.) as well as by a grant (2016-7017) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea. Publisher Copyright: © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Background and Aims: Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs. Methods: The intragastric satiety-inducing device (ISD) comprises a self-expandable esophageal metal stent connected to a star-shaped disc placed in the stomach fundus. Eight juvenile pigs were randomized into ISD (n = 5) and control (n = 3) groups. Body weight and serum ghrelin hormone were monitored weekly for 6 weeks. One pig was followed up for 4 additional weeks (rebound pig) after ISD removal. Histological examination and immunohistochemistry for the interstitial cells of Cajal (ICCs) were performed. Results: ISD placement was successful in all pigs. Two ISDs (40%) migrated at 4 and 5 weeks after placement. Weight gain rates were significantly lower in the ISD group than in the control group from week 1 to 6 but were higher in the rebound pig than in a control pig from week 7 to 10. Mean ghrelin hormone level was higher in the control group than in the ISD group from week 1 to 6. ISD induced reversible inflammatory changes in the esophagus and stomach fundus. The number of ICCs was lesser in ISD pigs than in control and rebound pigs. Conclusions: ISD placement is feasible and safe in juvenile pigs. It decreases weight gain rate but induces reversible inflammatory reaction and tissue hyperplasia. Its mechanism may be related to pressure exertion on the stomach fundus or gastric motility alteration.

AB - Background and Aims: Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs. Methods: The intragastric satiety-inducing device (ISD) comprises a self-expandable esophageal metal stent connected to a star-shaped disc placed in the stomach fundus. Eight juvenile pigs were randomized into ISD (n = 5) and control (n = 3) groups. Body weight and serum ghrelin hormone were monitored weekly for 6 weeks. One pig was followed up for 4 additional weeks (rebound pig) after ISD removal. Histological examination and immunohistochemistry for the interstitial cells of Cajal (ICCs) were performed. Results: ISD placement was successful in all pigs. Two ISDs (40%) migrated at 4 and 5 weeks after placement. Weight gain rates were significantly lower in the ISD group than in the control group from week 1 to 6 but were higher in the rebound pig than in a control pig from week 7 to 10. Mean ghrelin hormone level was higher in the control group than in the ISD group from week 1 to 6. ISD induced reversible inflammatory changes in the esophagus and stomach fundus. The number of ICCs was lesser in ISD pigs than in control and rebound pigs. Conclusions: ISD placement is feasible and safe in juvenile pigs. It decreases weight gain rate but induces reversible inflammatory reaction and tissue hyperplasia. Its mechanism may be related to pressure exertion on the stomach fundus or gastric motility alteration.

KW - Interstitial cells of Cajal

KW - Obesity

KW - Self-expandable metallic stents

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A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study

Abstract

Keywords

ASJC Scopus subject areas

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